Results 51 to 60 of about 6,804,228 (211)

Self-Reported Occupational Exposure to HIV and Factors Influencing its Management Practice: A Study of Healthcare Workers in Tumbi and Dodoma Hospitals, Tanzania. [PDF]

, 2013
Blood borne infectious agents such as hepatitis B virus (HBV), hepatitis C virus (HCV) and human immune deficiency virus (HIV) constitute a major occupational hazard for healthcare workers (HCWs).
Mubyazi, Godfrey M, Hamisi M Malebo, Mashoto, Kijakazi O, Mohamed, Hussein, Kijakazi O Mashoto, Malebo, Hamisi M, Hussein Mohamed, Godfrey M Mubyazi   +7 more
core   +2 more sources

sj-pdf-1-std-10.1177_09564624211068766 – Supplemental Material for Maintaining access to HIV pre-exposure prophylaxis in a pandemic: A service evaluation of telephone-based pre-exposure prophylaxis provision

, 2022
Supplemental Material, sj-pdf-1-std-10.1177_09564624211068766 for Maintaining access to HIV pre-exposure prophylaxis in a pandemic: A service evaluation of telephone-based pre-exposure prophylaxis provision by Lindsay Henderson, Jo Gibbs, Jacqueline ...
Jo Gibbs (3578741), Claudia Estcourt (3399986), Jacqueline Quinn (12450247), Sharmini Ramasami (12450250), Lindsay Henderson (4446877)   +4 more
core   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Are Thai MSM willing to take PrEP for HIV prevention? An analysis of attitudes, preferences and acceptance. [PDF]

, 2013
OBJECTIVE: We aimed to understand the attitudes, preferences and acceptance of oral and parenteral PrEP among men who have sex with men (MSM) in Thailand. BACKGROUND: Pre-exposure prophylaxis (PrEP), the use of antiretrovirals to prevent HIV acquisition,
Ana Wheelock, Wheelock, A, Gomez Gabriela B., Wheelock, Ana, Gomez, Gabriela B, Eisingerich, Andreas B., Hallett, Timothy B., Hallett, TB, Dybul Mark R., Dybul, MR, Gomez, Gabriela B., Dybul, Mark R., Dybul, Mark R, Hallett, Timothy B, Gomez, GB, Gabriela B Gomez, Piot Peter, Wheelock Ana, Hallett Timothy B., Andreas B Eisingerich, Piot, P, Peter Piot, Timothy B Hallett, Eisingerich, Andreas B, Eisingerich, AB, Piot, Peter, Ananworanich, J, Jintanat Ananworanich, Mark R Dybul, Ananworanich Jintanat, Ananworanich, Jintanat, Eisingerich Andreas B.   +31 more
core   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Pre-exposure prophylaxis for HIV prevention in women: current perspectives

, 2017
Charlene A Flash,1 Sannisha K Dale,2–4 Douglas S Krakower3,5,6 1Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, TX, 2Massachusetts General Hospital, 3Department of Psychiatry, Harvard Medical School ...
Krakower DS, Flash CA, Dale SK
core  

Essential Updates in the Surgical Management of Inflammatory Bowel Disease: Current Topics From 2024 to Mid‐2026

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Inflammatory bowel disease management has undergone a major transformation with the introduction of treat‐to‐target strategies and highly effective biologic and small‐molecule therapies. Although these advances have reduced the overall requirement for surgery, operative intervention remains essential for selected patients with ulcerative ...
Yoshiki Okita, Tadanobu Shimura, Mikio Kawamura, Yuhki Koike, Yuji Toiyama   +4 more
wiley   +1 more source