Results 61 to 70 of about 6,804,228 (211)

HOPE Kids 2: Phase 3, Randomized Trial of Voxelotor in Children With SCD and Conditional Cerebral Blood Flow Velocities

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Children with SCD have elevated stroke risk, correlated with cerebral blood flow velocity (CBFV). HOPE Kids 2 was a phase 3, multicenter, double‐blind, placebo‐controlled trial evaluating the effect of voxelotor on CBFV. Participants aged 2 to < 15 years with SCD (HbSS/HbSβ0) and conditional CBFV (170 to < 200 cm/s) were randomized 1:1 to ...
Halima Bello‐Manga   +58 more
wiley   +1 more source

Health Students' Knowledge of Pre-Exposure Prophylaxis (PrEP) and Post-Exposure Prophylaxis (PEP): A Scoping Review

open access: yes
Pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) are important tools for the prevention and reduction of human immunodeficiency virus (HIV) infections.
Laura Candeias dos Santos
core   +1 more source

Polarised press reporting about HIV prevention: Social representations of pre-exposure prophylaxis in the UK press [PDF]

open access: yes, 2016
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Pre-exposure prophylaxis is a novel biomedical HIV prevention option for individuals at high risk of HIV ...
Jaspal, R   +4 more
core   +1 more source

Chromosomal Abnormalities, Drug Sensitivity and Resistance in Hematological Malignancies: A Comprehensive Overview by the Francophone Group of Hematological Cytogenetics (GFCH)

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Chromosomal abnormalities have a major clinical impact on hematological malignancies, particularly with regard to treatment strategies. To preserve and consolidate fundamental knowledge in this rapidly evolving field, the Francophone Group of Hematological Cytogenetics (Groupe Francophone de Cytogénétique Hématologique, GFCH) conducted a ...
Florence Nguyen‐Khac   +16 more
wiley   +1 more source

Ac‐SDKP modulates apoptosis via HSP27 and the FAS/FASL and mitochondrial axes

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Schematic diagram of Ac‐SDKP regulating the FAS/FASL and mitochondrial apoptosis pathways via HSP27. Ac‐SDKP inhibits HSP27 expression, activates the FAS/FASL pathway and Caspase‐3 signaling, increases Caspase‐8 and Caspase‐3 expression, and induces cell apoptosis.
Wenxin Guo   +13 more
wiley   +1 more source

Use of a Reduced (4-dose) Vaccine Schedule for Postexposure Prophylaxis to Prevent Human Rabies : Recommendations of the Advisory Committee on Immunization Practices [PDF]

open access: yes
"These recommendations of the Advisory Committee on Immunization Practices (ACIP) update the previous recommendations on human rabies prevention (CDC.

core  

PrEP counseling center

open access: yes, 2023
This is a brochure for the PrEP Counseling Center. The PrEP Counseling Center is a virtual environment where clients who are prescribed PrEP (pre-exposure prophylaxis) in the Health Department Clinics can receive comprehensive PrEP ...
South Carolina Department of Health and Environmental Control
core  

ANK1 and EPB41 Variants and The Risk of Glucocorticoid‐Induced Osteonecrosis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen   +21 more
wiley   +1 more source

HIV Pre-Exposure Prophylaxis: Statewide Plan and Guidance

open access: yes
The South Carolina Department of Health and Environmental Control (DHEC) HIV Pre-exposure Prophylaxis (PrEP) Statewide Plan and Guidance has been developed by DHEC as an element of the PrEPMeSC initiative.
Department of Health and Environmental Control. Division of STD/HIV and Viral Hepatitis
core  

Efficacy and Safety of Nanoencapsulated Sirolimus Plus Pegadricase: Results From the Randomized, Placebo‐Controlled Phase 3 Trials

open access: yesArthritis &Rheumatology, EarlyView.
Objective DISSOLVE I and II examined the efficacy and safety of nanoencapsulated sirolimus (NAS) plus pegadricase (NASP) in patients with uncontrolled gout (UG). Methods In these double‐blind, placebo‐controlled Phase 3 trials of NASP, patients were randomized 1:1:1 to infusions of high‐dose (HD) or low‐dose (LD) NAS plus pegadricase (HD NASP, LD NASP,
Herbert S. B. Baraf   +15 more
wiley   +1 more source

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