Results 61 to 70 of about 135,172 (298)

Assessment of acceptance and associated factors of HIV pre-exposure prophylaxis among commercial female sex workers in drop-in centers selected sub-cities of Addis Ababa, Ethiopia

Frontiers in Public Health
BackgroundGlobally, female sex workers (FSWs) face high risk of HIV, particularly in regions like sub-Saharan Africa. In Ethiopia and Addis Ababa, the impact is significant.
Trhas Tadesse Berhe, Elefie Asfaw Asfaw, Getachew Weldyohanes Tedla   +2 more
doaj   +1 more source

Baseline Preferences for Daily, Event-Driven, or Periodic HIV Pre-Exposure Prophylaxis among Gay and Bisexual Men in the PRELUDE Demonstration Project

Frontiers in Public Health, 2017
IntroductionThe effectiveness of daily pre-exposure prophylaxis (PrEP) is well established. However, there has been increasing interest in non-daily dosing schedules among gay and bisexual men (GBM).
Stefanie J. Vaccher, Christopher Gianacas, David J. Templeton, David J. Templeton, Isobel M. Poynten, Bridget G. Haire, Catriona Ooi, Catriona Ooi, Rosalind Foster, Rosalind Foster, Anna McNulty, Anna McNulty, Andrew E. Grulich, Iryna B. Zablotska, On Behalf of the PRELUDE Study Team, Andrew Carr, Andrew Grulich, Anna McNulty, Brent Mackie, Cathy Pell, Catriona Ooi, Cheung (Yvonne) Ching, Chris Gianacas, David Templeton, Dean Murphy, Edwina Wright, Garrett Prestage, Isobel (Mary) Poynten, John de Wit, John Kaldor, John McAllister, Kenneth Mayer, Mark Bloch, Martin Holt, Nathan Ryder, Rebecca Guy, Rosalind Foster, Stefanie Vaccher   +37 more
doaj   +1 more source

Perceptions about HIV pre-exposure prophylaxis among healthcare professionals in Spain (PERPPRES Study) [PDF]

Farmacia Hospitalaria, 2016
Objective: To determine the level of support, knowledge and perceptions of pre-exposure prophylaxis (PrEP) by Infectious Disease Specialists and Hospital Pharmacists in Spain.
Javier Sánchez-Rubio Ferrández, José Manuel Martínez Sesmero, Herminia Navarro Aznárez, Sergio Fernández Espínola, Ismael Escobar Rodríguez, José Manuel Ventura Cerdá   +5 more
doaj   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Transformation of Australian Community Pharmacies Into Good Clinical Practice Compliant Trial Pharmacies for HIV Pre-Exposure Prophylaxis

Frontiers in Pharmacology, 2019
Background: In Australia, clinical trial drugs are conventionally dispensed through clinical trial pharmacies only, while community pharmacies dispense drugs approved by Australia’s regulatory body.
Luxi Lal, Luxi Lal, Luxi Lal, Kathleen Ryan, Kathleen Ryan, Iris Yi Liu, Brian Price, Timmy Lockwood, Ivette Aguirre, Peter Slobodian, Ada Lam, Manoj Vassan, Kie Lim, John Silverii, Joseph Tesoriero, Johnny Phu, Wan Lim, Bharathy Naidoo, Nick Russell, Matthew Rundle, Rowan Sewell, Craig Cooper, Alexander Hardman, Martin Quinn, Anne Mak, Edwina J. Wright, Edwina J. Wright, Edwina J. Wright, Edwina J. Wright   +28 more
doaj   +1 more source

Epidemiology and potential preventative measures for viral infections in children with malignancy and those undergoing hematopoietic cell transplantation. [PDF]

, 2012
In pediatric patients with malignancy and those receiving hematopoietic stem cell transplants, bacterial and fungal infections have been the focus of fever and neutropenia episodes for decades.
Alexander, Sarah, Dvorak, Christopher C, Fisher, Brian T, Sung, Lillian, Zaoutis, Theoklis E, Zerr, Danielle M   +5 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Comparing Self-Report Pre-Exposure Prophylaxis Adherence Questions to Pharmacologic Measures of Recent and Cumulative Pre-Exposure Prophylaxis Exposure

Frontiers in Pharmacology, 2019
As pre-exposure prophylaxis (PrEP) effectiveness is strongly linked to adherence, we sought to determine if certain self-report measures could be used to inform objective PrEP adherence.
Jill Blumenthal, Elizabeth C. Pasipanodya, Sonia Jain, Shelly Sun, Eric Ellorin, Sheldon Morris, David J. Moore   +6 more
doaj   +1 more source