Results 41 to 50 of about 65,616 (255)

Assessment of acceptance and associated factors of HIV pre-exposure prophylaxis among commercial female sex workers in drop-in centers selected sub-cities of Addis Ababa, Ethiopia

Frontiers in Public Health
BackgroundGlobally, female sex workers (FSWs) face high risk of HIV, particularly in regions like sub-Saharan Africa. In Ethiopia and Addis Ababa, the impact is significant.
Trhas Tadesse Berhe, Elefie Asfaw Asfaw, Getachew Weldyohanes Tedla   +2 more
doaj   +1 more source

Perceptions about HIV pre-exposure prophylaxis among healthcare professionals in Spain (PERPPRES Study) [PDF]

Farmacia Hospitalaria, 2016
Objective: To determine the level of support, knowledge and perceptions of pre-exposure prophylaxis (PrEP) by Infectious Disease Specialists and Hospital Pharmacists in Spain.
Javier Sánchez-Rubio Ferrández, José Manuel Martínez Sesmero, Herminia Navarro Aznárez, Sergio Fernández Espínola, Ismael Escobar Rodríguez, José Manuel Ventura Cerdá   +5 more
doaj   +1 more source

Pre-exposure rabies prophylaxis: a systematic review

Bulletin of the World Health Organization, 2016
To review the safety and immunogenicity of pre-exposure rabies prophylaxis (including accelerated schedules, co-administration with other vaccines and booster doses), its cost-effectiveness and recommendations for use, particularly in high-risk settings.We searched the PubMed, Centre for Agriculture and Biosciences International, Cochrane Library and ...
Kessels, Jocelyn A., Recuenco, Sergio, Briggs, Deborah, Navarro-Vela, Ana Maria, Deray, Raffy, Vigilato, Marco, Ertl, Hildegund, Durrheim, David, Rees, Helen, Nel, Louis H., Abela-Ridder, Bernadette   +10 more
openaire   +5 more sources

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Transformation of Australian Community Pharmacies Into Good Clinical Practice Compliant Trial Pharmacies for HIV Pre-Exposure Prophylaxis

Frontiers in Pharmacology, 2019
Background: In Australia, clinical trial drugs are conventionally dispensed through clinical trial pharmacies only, while community pharmacies dispense drugs approved by Australia’s regulatory body.
Luxi Lal, Luxi Lal, Luxi Lal, Kathleen Ryan, Kathleen Ryan, Iris Yi Liu, Brian Price, Timmy Lockwood, Ivette Aguirre, Peter Slobodian, Ada Lam, Manoj Vassan, Kie Lim, John Silverii, Joseph Tesoriero, Johnny Phu, Wan Lim, Bharathy Naidoo, Nick Russell, Matthew Rundle, Rowan Sewell, Craig Cooper, Alexander Hardman, Martin Quinn, Anne Mak, Edwina J. Wright, Edwina J. Wright, Edwina J. Wright, Edwina J. Wright   +28 more
doaj   +1 more source

Pre-Exposure Prophylaxis for HIV: Evidence and Perspectives

Current Pharmaceutical Design, 2017
HIV remains an important public health issue worldwide. However, new prevention approaches have recently been developed and are very promising. Antiretroviral treatment as prevention, or as a prophylaxis after exposure to HIV, has been shown to reduce the likelihood of HIV acquisition.
Nikolopoulos, Georgios K., Christaki, Eirini, Paraskeva, D., Bonovas, Stefanos, Nikolopoulos, Georgios K., Christaki, Eirini, Paraskeva, D., Bonovas, Stefanos   +7 more
openaire   +4 more sources

Pre-Exposure Prophylaxis for HIV Prevention: Safety Concerns [PDF]

Drug Safety, 2017
Available evidence supports the efficacy of pre-exposure prophylaxis (PrEP) in decreasing the incidence of human immunodeficiency virus (HIV) infection among high-risk individuals, especially when used in combination with other behavioural preventive methods. Safety concerns about PrEP present challenges in the implementation and use of PrEP.
Tetteh, Raymond A, Yankey, Barbara A, Nartey, Edmund T, Lartey, Margaret, Leufkens, Hubert G M, Dodoo, Alexander N O   +5 more
openaire   +3 more sources

Combining Radiation‐Treated Tumor Vaccines With Mn‐MOF Nanoadjuvants to Amplify Radiation Induced Anti‐Tumor Immune Responses

Advanced Science, EarlyView.
Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang, Qiqi Qi, Dezhong Li, Jingshi Tang, Weifeng Wang, Zushun Xu, Qi Xu, Fangfang Du, Qianyuan He   +8 more
wiley   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

Choosing a metric for measurement of pre-exposure prophylaxis [PDF]

The Lancet Infectious Diseases, 2014
As the results of HIV prevention trials transition to public health practice, Susan Buchbinder and colleagues1 have provided a timely exploration of how to prioritise the targeting of pre-exposure prophylaxis (PrEP) to men who have sex with men (MSM). They have drawn attention to the need to examine the efficiency of PrEP in seroconversion prevention ...
Ruth, Emerson, Sarah, Emerson, Deborah, Donnell, James P, Hughes   +3 more
openaire   +5 more sources