Results 81 to 90 of about 135,172 (298)

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Pre-exposure prophylaxis (PrEP) means more exposure?

DST, 2018
During the last Conference for the Prevention of Sexually Transmitted Diseases of the Centers for Disease Control and Prevention (CDC-USA), in 2018, the advent of a new era in the fight against HIV infection was very clear(1).
Andrea Menezes Gonçalves
doaj  

Low clinical impact of HIV drug resistance mutations in oral pre-exposure prophylaxis: a systematic review and meta-analysis

AIDS Research and Therapy
Introduction Despite the widespread use of pre-exposure prophylaxis (PrEP) in preventing human immunodeficiency virus (HIV) transmission, scant information on HIV drug resistance mutations (DRMs) has been gathered over the past decade.
Brian Eka Rachman, Siti Qamariyah Khairunisa, Citrawati Dyah Kencono Wungu, Tri Pudy Asmarawati, Musofa Rusli, Bramantono, M. Vitanata Arfijanto, Usman Hadi, Masanori Kameoka, Nasronudin   +9 more
doaj   +1 more source

Characteristics of a cohort of high-risk men who have sex with men on pre-exposure prophylaxis reporting transgender sexual partners. [PDF]

, 2019
Transgender people continue to be at high-risk for HIV acquisition, but little is known about the characteristics of their sexual partners. To address this gap, we examined sociodemographic and sexual characteristics of cisgender men who have sex with ...
Blumenthal, Jill S, Corado, Katya, Dube, Michael P, Ellorin, Eric, Hassan, Adiba, Moore, David J, Morris, Sheldon R, Wertheim, Joel O   +7 more
core  

Experiences with HPTN 067/ADAPT Study-Provided Open-Label PrEP Among Women in Cape Town: Facilitators and Barriers Within a Mutuality Framework. [PDF]

, 2017
Placebo-controlled trials of pre-exposure prophylaxis (PrEP) have reported challenges with study-product uptake and use, with the greatest challenges reported in studies with young women in sub-Saharan Africa.
Amico, K Rivet, Atujuna, Millicent, Bekker, Linda-Gail, Dye, Bonnie J, Elharrar, Vanessa, Grant, Robert M, Roux, Surita, Sebastian, Elaine, Wallace, Melissa   +8 more
core   +2 more sources

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

Remediated sexuality: the meanings of postand pre-exposure prophylaxis for HIV [PDF]

Saúde e Sociedade
This article discusses the sexual character of HIV preand post-exposure prophylaxis (PEP and PrEP, respectively). It derives from a socio-anthropological study on the biomedicalization of responses to HIV that analyzed the offer of these prophylaxes in ...
Mauro Brigeiro, Simone Monteiro
doaj   +1 more source

New Approaches to HIV Prevention: Accelerating Research and Ensuring Future Access [PDF]

, 2006
Summarizes the state of research on new HIV prevention approaches and recommends ways to accelerate research and ensure rapid access to new prevention ...

core  

Significance of Self‐Expandable Metallic Stent for Postoperative Intra‐Abdominal Infection After Pancreatoduodenectomy in Patients With a Hard Pancreas

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Self‐expandable metal stents (SEMS) are often used for preoperative biliary drainage in pancreatoduodenectomy (PD); however, their impact on postoperative intra‐abdominal infection (POAI) remains unclear. This study aimed to evaluate the clinical significance of SEMS in relation to POAI.
Kosuke Mori, Haruyoshi Tanaka, Nana Kimura, Mina Fukasawa, Ayaka Itoh, Yoshihiro Shirai, Kazuto Shibuya, Kentaro Nagaoka, Yoshihiro Yamamoto, Tsutomu Fujii   +9 more
wiley   +1 more source

Evidence-Based Study of Medication Compliance Project in Hiv Prevention Using Pre-Exposure Prophylaxis (Prep) Antivirals for HIV-Negative Males [PDF]

, 2018
In 2012, emtricitabine/tenofovir was the only Food and Drug Administration-approved medication for pre-exposure prophylaxis (PrEP) used in human immunodeficiency virus (HIV) prevention.
Ho, Ming-Chun
core   +1 more source