Results 101 to 110 of about 135,172 (298)

Routes of Human Rabies Infection and Prophylaxis as Methods of Prevention

Quality in Sport
The rabies virus is responsible for one of the most severe diseases transmitted from animals to humans. Rabies is associated with an almost 100% case-fatality rate once clinical symptoms develop.
Kacper Dąbrowski, Natalia Leśniewska, Bartłomiej Szymulewicz , Jakub Łukaszewicz , Małgorzata Niewęgłowska , Paulina Walczak , Aleksandra Bender , Katarzyna Widomska , Mateusz Bernad , Oliwia Krazińska , Magdalena Gałach   +10 more
doaj   +1 more source

Progress in prevention of mother-to-child transmission of HIV infection in Ukraine: results from a birth cohort study [PDF]

, 2009
Background: Ukraine was the epicentre of the HIV epidemic in Eastern Europe, which has the most rapidly accelerating HIV epidemic world-wide today; national HIV prevalence is currently estimated at 1.6%.
Malyuta, R, Pilipenko, T, Semenenko, I, Thorne, C, Ukraine European Collaborative Study Group, The   +4 more
core  

Pharmacokinetic modelling of intravenous immunoglobulin in children with primary immunodeficiencies and secondary antibody deficiencies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Children with primary immunodeficiency (PID) and secondary antibody deficiency (SAD) often require immunoglobulin replacement therapy due to low plasma immunoglobulin G (IgG) levels and recurrent infections. Existing pharmacokinetic models for immunoglobulin in PID patients predominantly focus on adults, with limited attention to ...
Iek Leng Cheng, Zhong Hui Huang, Austen Worth, Claire Booth, Joseph F. Standing   +4 more
wiley   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

British Journal of Clinical Pharmacology, EarlyView.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp, Martijn L. Manson, Henk‐Jan Guchelaar, Stefan Böhringer, Esther H. M. van Egmond, Peter A. von dem Borne, Jesse J. Swen   +6 more
wiley   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Exploring Barriers and Facilitators That Influence Uptake of Oral Pre-Exposure Prophylaxis Among Men Who Have Sex With Men in Bulawayo, Zimbabwe: Key Stakeholder’s Perspectives

American Journal of Men's Health
The world has been on the path to ending HIV and AIDS as a global threat by 2030; despite these efforts, the rate of new HIV infections among men who have sex with men remains very high. This study sought to explore the perceptions of key stakeholders on
Perez Livias Moyo, Wilfred Njabulo Nunu
doaj   +1 more source

POPULATION KNOWLEDGE AND PERCEPTIONS ABOUT HIV, SEROPHOBIA, PREP, AND PEP IN FORTALEZA

Brazilian Journal of Infectious Diseases
Introduction/Objective: HIV infection remains a major global public health challenge, requiring integrated strategies for prevention, diagnosis, and treatment.
Vinicius Machado Salles, Mariana Jales Moura, Caroline Casemiro Gomes, Nathanael Willian Florencio de Freitas, Júlia Almeida Saraiva, Antonio Riquelme Martins Negreiros, Anna Paula Nogueira Nascimento, Thammy Lys Câmara Balbino, Manuel Eloy Leitão de Castro Junior, Lucas Passos Portácio Bezerra, Wirna Queiroz Belem Moreira, Lara Gurgel Fernandes Távora   +11 more
doaj   +1 more source

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

British Journal of Clinical Pharmacology, EarlyView.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert, Carl M. J. Kirkpatrick, Rory Marriott, Siladitya Ray Chaudhuri, David Polidori, Bart Remmerie, Michelle P. McIntosh   +6 more
wiley   +1 more source

Analysis of sexually transmitted infections in PrEP users: population assessment in Curitiba, Brazil

DST, 2022
Introduction: The pre-exposure prophylaxis (PrEP) is a globally recognized pharmacological approach, consisting of a daily dose of antiretroviral drugs used to reduce the contamination rate by the human immunodeficiency virus (HIV).
Maria Julia de Moraes Campos Roth, Mariana Rothermel Valderrama, Julia Schemberger Acras, Marjorie Goetz Moro, João Victor Borges Lehmkuhl, Daiane Cristina Pazin   +5 more
doaj