Results 111 to 120 of about 65,616 (255)

Hyperoside alleviates endometrial stromal cell senescence in unexplained recurrent spontaneous abortion via DHX9‐mediated R‐loop resolution

iMeta, EarlyView.
This study suggests that the food‐derived flavonoid hyperoside may act as a natural DExH‐box helicase 9 (DHX9) modulator, directly targeting Thr419 of DHX9 to help resolve pathological R‐loop accumulation. Consequently, it suppresses cyclic GMP‐AMP synthase‐stimulator of interferon genes (cGAS‐STING)‐driven endometrial stromal senescence and restores ...
Yuepeng Jiang, Hongli Zhao, Xinyi Ding, Haoling Zhang, Yadong Guo, Yiming Ma, Lingyi Cai, Qingnan Fan, Ruisi Peng, Fuyuan Yang, Doblin Sandai, Xianling Cao, Jiali Yao, Wenyi Wang, Zhiheng Lin, Wangzheqi Zhang, Jialin He, Aihua Zhang, Xiaoxuan Zhao   +18 more
wiley   +1 more source

Maternal and infant gut microbiome

iMeta, EarlyView.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Addressing Perceived Barriers to Achieving Competency in Clinical Endodontics: A Mixed‐Methods Study

Journal of Dental Education, EarlyView.
ABSTRACT Purpose/Objectives The aim of this study was to assess predoctoral dental students’ satisfaction with faculty‐created educational content, aimed at reducing perceived barriers to achieving clinical competency in endodontics. Methods: This mixed‐methods study was conducted with third (D3)‐ and fourth (D4)‐year dental students at New York ...
Min‐Wen Fu, Ali Adil, Lucia Wang, Lorel E. Burns   +3 more
wiley   +1 more source

Immersive Technologies in Dental Education: Global Adoption Patterns From a 2025 Survey

Journal of Dental Education, EarlyView.
ABSTRACT Purpose/Objectives Dental education is undergoing a digital transformation, yet the adoption of immersive technologies such as haptic virtual reality (HVR) remains limited. This study aimed to map global adoption trends, barriers, and opportunities for equitable integration of HVR in dental curricula.
Barry Quinn, Reinhard Chun Wang Chau, Szabolcs Felszeghy, Mikko Liukkonen, Andreea Cristiana Didilescu, Damiano Pasqualini, Daniela Pino Valenzuela, David P. Rice, Gianrico Spagnuolo, Josette Camilleri, Khaled E. Ahmed, Laura Andriukaitiene, Łukasz Zadrożny, Masako Nagasawa, Mengwei Pang, Mohammed Al‐Haroni, Neshka Manchorova, Nisrine El Arrouf, Noha Waleed Barakat, Peter Lingström, Samantha J. Byrne, Santiago Arias‐Herrera, Ülle Voog‐Oras, Gitana Rederiene, Gül Gülsün, Rebecca Stolberg, Henry F. Duncan, Sompop Bencharit, Margaret Cox   +28 more
wiley   +1 more source

An Exploratory Comparative Analysis of Mixed Reality Simulation Versus 3D‐Printed Models for Undergraduate Training in Third Molar Removal

Journal of Dental Education, EarlyView.
ABSTRACT Purpose/Objectives To compare the effectiveness of MR simulation and 3D‐printed models in training undergraduate students in wisdom tooth removal, and to assess students’ perceptions of the MR simulator. Methods Students trained first on either the MR simulator or 3D‐printed plastic models and then repeated the training using the other method ...
Ruza Bjelovucic, Bruna Neves de Freitas, Sven Erik Nørholt, Pankaj Taneja, Jan Wolff, Ruben Pauwels   +5 more
wiley   +1 more source

Clinical progress note: Mumps

Journal of Hospital Medicine, EarlyView.
Abstract Mumps was a common childhood viral illness before the implementation of the measles, mumps, and rubella (MMR) vaccination in 1967. There was a significant decrease in mumps cases in the postvaccine era; however, there has been an increase in outbreaks in the United States over the past two decades.
Sarah Ludvigsen, Mati Segev
wiley   +1 more source

Biomaterials for resolution of peri‐implantitis: Consensus report of Workgroup 2 of the IADR Implantology Research Group Best Evidence Consensus Symposium on Peri‐Implant Disease and Its Treatment

Journal of Periodontology, EarlyView.
Abstract Background Peri‐implantitis is a destructive disease affecting the tissues surrounding dental implants. Biomaterials may be applied during surgical treatment to reconstruct bony defects and support soft tissue healing. However, current evidence is unclear if these treatments increase the likelihood of peri‐implantitis resolution.
Sukirth M. Ganesan, David R. Fraser, Mustafa Tattan, Jessica M. Latimer, IADR IRG Peri‐Implantitis Best Evidence Consensus Working Group 2, Mario Aimetti, Hatice Hasturk, Purnima S. Kumar, Fernando Suarez Lopez Del Amo, Andreas Stavropoulos, Daniel S. Thoma, Spyridon Vassilopoulos, Hom‐Lay Wang, Georgios Kotsakis   +13 more
wiley   +1 more source

Lenacapavir as pre-exposure prophylaxis for HIV prevention. [PDF]

Cochrane Database Syst Rev
Ebrahim S, Gloeck N, Adam Z, Tatz G, Nel J, Sinxadi PZ, Dawood H, Kredo T, Cohen K.   +8 more
europepmc   +1 more source

Mapping the subgingival HerBiome and HisBiome over the human healthspan

Journal of Periodontology, EarlyView.
Abstract Background Understanding the intricate relationship between sex, age, and the oral microbiome is crucial for deciphering the onset and progression of numerous age‐related oral and systemic diseases. Methods Subgingival plaque was collected from 781 periodontally and systemically healthy females and 160 males spanning 0 to 80 years.
Rahul Nikam, Kazune Pax, Michelle Lee‐Scott Beverly, Purnima S. Kumar   +3 more
wiley   +1 more source