Results 101 to 110 of about 8,261,594 (295)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Pre–Heart Failure Longitudinal Change in a Hispanic/Latino Population-Based Study

, 2023
BACKGROUND Pre-heart failure (pre-HF) is an entity known to progress to symptomatic heart failure (HF).OBJECTIVES This study aimed to characterize pre-HF prevalence and incidence among Hispanics/Latinos.METHODS The Echo-SOL (Echocardiographic Study of ...
Talavera, Gregory A., Sonia G. Ponce, Nestor Vasquez, Mayank M. Kansal, Katrina Swett, Kuno, Toshiki, Thyagarajan, Bharat, Kansal, Mayank M., Carlos J. Rodriguez, Toshiki Kuno, Gregory A. Talavera, Cai, Jianwen, Kitzman, Dalane, Ayana K. April-Sanders, Daviglus, Martha L., Bharat Thyagarajan, Jorge R. Kizer, Dalane Kitzman, Penedo, Frank J., Vasquez, Nestor, Frank J. Penedo, Swett, Katrina, Rodriguez, Carlos J., Martha L. Daviglus, Jianwen Cai, April-Sanders, Ayana K., Ponce, Sonia G., Bonnie E. Shook-Sa, Kizer, Jorge R., Shook-Sa, Bonnie E.   +29 more
core   +1 more source

Damage evolution in marble under uniaxial compression monitored by Pressure Stimulated Currents and Acoustic Emissions

Fracture and Structural Integrity, 2019
The spatiotemporal evolution of damage in marble speci­mens under uniaxial compression is monitored using Pressure Stimulated Currents (PSCs) and Acoustic Emissions (AEs). The novelty of the study is the use of an integrated grid of sensors (instead of a
Ilias Stavrakas, Stavros Kourkoulis, Dimos Triantis   +2 more
doaj   +3 more sources

Injury Prevention Indicators for Inuit Children and Youth

, 2010
First Nations and Inuit children and youth indicators are important tools to influence policy and to measure community‐specific aspects of health and wellness in a First Nations context.
First Nations and Inuit Children and Youth Injury Indicators Working Group, Pike, Ian, 1958-   +1 more
core   +2 more sources

Sedation Management for Critically Ill Children with Pre-Existing Cognitive Impairment

Jornal de Pediatria, 2018
Objective To compare current analgesia and sedation management practices between critically ill children with pre‐existing cognitive impairment and critically ill neurotypical children, including possible indicators of therapeutic efficacy.
K. Best, L. Asaro, M. Curley, David Wypij, Geoffrey L. Allen, D. Angus, Judy A. Ascenzi, Scot T. Bateman, S. Borasino, Cindy Darnell Bowens, Kris G. Bysani, Ira M. Cheifetz, Allison S. Cowl, Brenda L. Dodson, Vincent S. E. Faustino, Lori D. Fineman, Heidi R. Flori, L. Franck, Rainer G. Gedeit, Mary Jo C. Grant, Andrea L. Harabin, Catherine Haskins-Kiefer, J. Hertzog, Larissa Hutchins, A. Kirby, Ruth M. Lebet, M. Matthay, G. McLaughlin, J. Natale, Phineas P. Oren, Nagendra Polavarapu, James B. Schneider, A. Schwarz, T. Shanley, Shari Simone, L. Singer, Lauren R. Sorce, E. Truemper, Michele A. Vander Heyden, S. Watson, Claire R. Wells   +40 more
semanticscholar   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The EuroHeart Failure survey programme—a survey on the quality of care among patients with heart failure in Europe Part 1: patient characteristics and diagnosis [PDF]

, 2003
The European Society of Cardiology (ESC) has published guidelines for the investigation of patients with suspected heart failure and, if the diagnosis is proven, their subsequent management.
van Gilst, WH, Eastaugh, Joanne, Cohen-Solal, A., Gilst, W. H. van, Gavazzi, A, Freemantle, N, Cleland, JG, Gavazzi, A., Hobbs, Frederick, Moiseyev, VS, Dietz, R, van Gilst, W.H., Cleland, J.G., Hobbs, R, Korewicki, J., Follath, F., Hobbs, R., Mason, J., Eastaugh, J, Cohen-Solal, A, Préda, István, Cleland, JGF, Freemantle, Nick, Madeira, HC, Widimsky, J, Swedberg K Follath, F, Dietz, R., Cleland, J. G. F., Widimsky, J., Swedberg, K, Eastaugh, J., Preda, [No Value], Madeira, H. C., Moiseyev, V. S., Aguilar, JC, Aguilar, J.C., Komajda, M., Freemantle, N., Komajda, M, Preda, I., Korewicki, J, Aguilar, J. C., Mason, J, Madeira, H.C., Preda, I, Moiseyev, V.S., Swedberg, K., Follath, F   +47 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source