Results 81 to 90 of about 8,261,594 (295)
Prognostic value of genome-wide methylation in acute-on-chronic hepatitis B liver failure.
Pathology, Research and PracticeAIM Methylation status of genome varies between pre-acute-on-chronic hepatitis B liver failure (pre-ACHBLF), acute-on-chronic hepatitis B liver failure (ACHBLF), and chronic hepatitis B patients.
Hai-Ming Li +6 more
semanticscholar +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Pre-mRNA mis-splicing of sarcomeric genes in heart failure
, 2018 Pre-mRNA splicing is an important biological process that allows production of multiple proteins from a single gene in the genome, and mainly contributes to protein diversity in eukaryotic organisms.
Wei Guo (86150) +2 more
core +1 more source
MathematicsWe develop a closed-form analysis of the joint distribution for cumulative shock reliability systems with phase-type inter-shock times. The analytical literature on shock-driven reliability has hitherto been split into two largely separate traditions ...
Lotfi Tadj
doaj +1 more source
Romanian Journal of CardiologyBackground Heart failure (HF) is a leading cause of hospitalization and mortality worldwide, with a substantial burden in Central and Eastern Europe.
O. Chioncel +7 more
semanticscholar +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Вестник трансплантологии и искусственных органов, 2019 Aim: the aim of the study was a comparative assessment of the quality of life of recipients with donor heart at the stages before and after heart transplantation.Materials and methods: the study included 150 patients who underwent orthotopic heart ...
S. V. Gautier +12 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
ResilientWireless Sensor Networks Using Topology Control: A Review
Sensors, 2015 Wireless sensor networks (WSNs) may be deployed in failure-prone environments, and WSNs nodes easily fail due to unreliable wireless connections, malicious attacks and resource-constrained features. Nevertheless, if WSNs can tolerate at most losing k - 1
Yuanjiang Huang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source