Results 91 to 100 of about 8,261,594 (295)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Acoustic Emission Analysis of Cement Mortar Specimens During Three Point Bending Tests

Latin American Journal of Solids and Structures
This work discusses the experimental results of Acoustic Emission (AE) recordings during repetitive loading/unloading loops of cement mortar beams subjected to three point bending.
I. Stavrakas, D. Triantis, S.K. Kourkoulis, E.D. Pasiou, I. Dakanali   +4 more
doaj   +1 more source

Assessment of crack stress thresholds and development of a pre-failure indicator using Digital Image Correlation approach for coal specimen

Geomechanics and Geophysics for Geo-Energy and Geo-Resources, 2021
Nutan Shukla, Manoj Kumar Mishra
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

An assessment of failure to rescue derived from routine NHS data as a nursing sensitive patient safety indicator (report to Policy Research Programme)

, 2010
Objectives: This study aims to assess the potential for deriving 2 mortality based failure to rescue indicators and a proxy measure, based on exceptionally long length of stay, from English hospital administrative data by exploring change in coding ...
Jones, Simon, Bottle, Alex, Griffiths, Peter   +2 more
core   +1 more source

Combining clinical markers can predict mortality in NYHA IV heart failure

Scientific Reports
Early assessment of heart failure during treatment can improve patient prognosis. Brain natriuretic peptide (BNP), uric acid (UA), pre-albumin (PA), red blood cell distribution width (RDW), and Cystatin C (Cys C) are related to the development of heart ...
Yi-jiao Men, Yan-ling Dong, Yu Gong, Ya-qing An, Hong-bo Cheng   +4 more
doaj   +1 more source

T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

Nature, 2017
Despite the success of monotherapies based on blockade of programmed cell death 1 (PD-1) in human melanoma, most patients do not experience durable clinical benefit.
Alexander C. Huang, M. Postow, R. Orlowski, R. Mick, Bertram Bengsch, Sasikanth Manne, Wei Xu, Shannon Harmon, Josephine R. Giles, Brandon M. Wenz, Matthew Adamow, D. Kuk, K. Panageas, C. Carrera, P. Wong, Felix Quagliarello, B. Wubbenhorst, K. D'Andrea, Kristen E. Pauken, R. Herati, Ryan P. Staupe, J. Schenkel, S. McGettigan, S. Kothari, Sangeeth M. George, R. Vonderheide, R. Amaravadi, G. Karakousis, L. Schuchter, Xiaowei Xu, K. Nathanson, J. Wolchok, T. Gangadhar, E. Wherry   +33 more
semanticscholar   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Quality Assurance Indicators of Long-Term Care in European Countries. ENEPRI Research Report No. 110, April 2012 [PDF]

, 2012
This study reports on the quality indicators that were collected by the ANCIEN project partners in each country considered in Work Package 5 (Quality in Long-Term Care).
Casanova, Georgia, Dandi, Roberto
core