Results 71 to 80 of about 172,940 (266)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

An assessment of failure to rescue derived from routine NHS data as a nursing sensitive patient safety indicator (report to Policy Research Programme)

, 2010
Objectives: This study aims to assess the potential for deriving 2 mortality based failure to rescue indicators and a proxy measure, based on exceptionally long length of stay, from English hospital administrative data by exploring change in coding ...
Jones, Simon, Bottle, Alex, Griffiths, Peter   +2 more
core  

EVA and key performance indicators: The case of automotive sector in pre-crisis, crisis and post-crisis periods [PDF]

, 2018
The choice of a suitable measure for company's performance and identification of key performance indicators are among the most frequently discussed topics in the field of corporate management strategizing.
Pavelková, Drahomíra, Pham, Ha, Homolka, Lubor, Knápková, Adriana, Kolman, Karel   +4 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Comparison of indicators pre-COVID-19 and during COVID-19.

, 2023
Comparison of indicators pre-COVID-19 and during COVID-19.
Diana M. Gibb (7866269), Michelle Heys (272934), Angela Mushavi (188619), Anesu Chimwaza (8072375), Ngoni Manika (16827835), Mutsa Bwakura-Dangarembizi (3480167), Zivai Mupambireyi Nenguke (16827838), Simbarashe Chimhuya (5167196), Elizabeth Chappell (4807257), Frances Cowan (19823), Felicity Fitzgerald (13958608), Deborah Ford (628145), Hannah Gannon (14284990), Tom Gibb (16827841), Andrew Phillips (201315), Catherine J. Wedderburn (7439045)   +15 more
core   +1 more source

Acoustic Emission Analysis of Cement Mortar Specimens During Three Point Bending Tests

Latin American Journal of Solids and Structures
This work discusses the experimental results of Acoustic Emission (AE) recordings during repetitive loading/unloading loops of cement mortar beams subjected to three point bending.
I. Stavrakas, D. Triantis, S.K. Kourkoulis, E.D. Pasiou, I. Dakanali   +4 more
doaj   +1 more source

Assessment of crack stress thresholds and development of a pre-failure indicator using Digital Image Correlation approach for coal specimen

Geomechanics and Geophysics for Geo-Energy and Geo-Resources, 2021
Nutan Shukla, Manoj Kumar Mishra
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Determinants of the Venezuelan Banking Crisis of the Mid-1990s: An Event History Analysis [PDF]

This paper uses event history analysis to test the significance of several macro-economic and bank-specific variables in explaining bank failures during the Venezuelan banking crisis of the mid-1990s.
Alicia García Herrero
core  

A calendar based internet content pre-caching agent for small computing devices

, 2007
We described in earlier publications the principles of a system where Internet content would be pre-cached, based on contextual information obtained from a user's electronic calendar.
Komninos, Andreas, Dunlop, Mark D.
core   +1 more source