Results 141 to 150 of about 6,517,332 (327)

Development of the Architectural Simulation Model for Future Launch Systems and its Application to an Existing Launch Fleet

, 2005
A significant portion of lifecycle costs for launch vehicles are generated during the operations phase. Research indicates that operations costs can account for a large percentage of the total life-cycle costs of reusable space transportation systems ...
Rabadi, Ghaith
core  

A float-based Ocean color vicarious calibration program

Frontiers in Remote Sensing
Ocean color satellites require a procedure known as System Vicarious Calibration (SVC) after launch as the pre-launch and on-orbit calibration accuracy is insufficient.
Andrew Barnard, Emmanuel Boss, Nils Haëntjens, Cristina Orrico, Paul Chamberlain, Robert Frouin, Matthew Mazloff, Jing Tan   +7 more
doaj   +1 more source

What makes a compliant Phase III and pre-launch patient advocacy strategy? [PDF]

J Mark Access Health Policy, 2016
Hicks N, Allan K, Thalheim C, Woods P.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ExoMars: Pre-Launch PanCam Modeling and Accuracy Assessment

, 2012
The goal of this research is pre-launch quantitative analysis of the localization accuracy of the Panoramic Camera (PanCam) vision system designed to be carried onboard the European Space Agency (ESA) ExoMars rover mission for launch in ...
Li, R., Coates, A., Barnes, D. P., Griffiths, A., Oberst, J., Meng, X., Paar, G., Li, D., Di, K., Muller, J. P., Lin, L.   +10 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

29.69 S87-26067 USSR Launch

An image of a USSR ...

core  

Evaluation of the impact of convolution masks on algorithm to supervise scenery changes at space vehicle integration pads

Journal of Aerospace Technology and Management, 2011
The Satellite Launch Vehicle developed in Brazil employs a specialized unit at the launch center known as the Movable Integration Tower. On that tower, fixed and movable work floors are installed for use by specialists, at predefined periods of time ...
Francisco Carlos P. Bizarria, Silvana Aparecida Barbosa, José Walter P. Bizarria, João Maurício Rosário   +3 more
doaj