Results 41 to 50 of about 522,601 (266)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Planetary Obliquity Excitation through Pre-main-sequence Stellar Evolution

The Astrophysical Journal
A planet’s axial tilt (“obliquity”) substantially affects its atmosphere and habitability. It is thus essential to comprehend the various mechanisms that can excite planetary obliquities, particularly at the primordial stage.
Sidhant Kumar Suar, Sarah C. Millholland
doaj   +1 more source

A High-resolution Optical Survey of Upper Sco: Evidence for Coevolution of Accretion and Disk Winds

The Astrophysical Journal, 2023
Magnetohydrodynamic (MHD) and photoevaporative winds are thought to play an important role in the evolution and dispersal of planet-forming disks. Here, we analyze high-resolution (Δ v ∼ 7 km s ^−1 ) optical spectra from a sample of 115 T Tauri stars in ...
Min Fang, Ilaria Pascucci, Suzan Edwards, Uma Gorti, Lynne A. Hillenbrand, John M. Carpenter   +5 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Pre-Main-Sequence Stellar Evolution [PDF]

Symposium - International Astronomical Union, 1981
The problems of the stellar evolution to the main sequence are reviewed, taking into account the effects of mass loss, rotation and binarity. Properties of T Tauri stars are discussed which are connected with the recent observations of these stars in ultraviolet and X-ray regions. FU Ori phenomen is considered briefly.
openaire   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Effect of Time-varying X-Ray Emission from Stellar Flares on the Ionization of Protoplanetary Disks

The Astrophysical Journal
X-rays have significant impacts on cold, weakly ionized protoplanetary disks by increasing the ionization rate and driving chemical reactions. Stellar flares are explosions that emit intense X-rays and are the unique source of hard X-rays with an energy ...
Haruka Washinoue, Shinsuke Takasao, Kenji Furuya   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Anisotropic Ionizing Illumination from an M-type Pre-main-sequence Star, DM Tau

The Astrophysical Journal, 2023
The powerful, high-energy magnetic activities of young stars play important roles in the magnetohydrodynamics in the innermost parts of the protoplanetary disks. In addition, the associated UV and X-ray emission dictates the photochemistry; moreover, the
Yuka Terada, Hauyu Baobab Liu, David Mkrtichian, Jinshi Sai, Mihoko Konishi, Ing-Guey Jiang, Takayuki Muto, Jun Hashimoto, Motohide Tamura   +8 more
doaj   +1 more source