Results 81 to 90 of about 522,601 (266)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

An Eccentric Binary with a Misaligned Circumbinary Disk

The Astrophysical Journal Letters
We present spectroscopic and photometric observations of Bernhard-2, which was previously identified as a candidate system that hosts a misaligned circumbinary disk. Our spectroscopic measurements confirm that Bernhard-2 indeed contains an eccentric ( e =
Zhecheng Hu, Wei Zhu, Fei Dai, Ping Chen, Yang Huang, Min Fang, Richard S. Post   +6 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Radial differential rotation leading to dipole collapse in pre-main-sequence stars

Astronomy & Astrophysics
Context. Despite significant progress in the observational characterization of stellar magnetic fields, the physical processes that govern their intensity and topology, which could certainly result from their formation history, remain poorly understood ...
Guseva A., Manchon L., Petitdemange L., Pinçon C.   +3 more
doaj   +1 more source

A planet within the debris disk around the pre-main-sequence star AU Microscopii. [PDF]

Nature, 2020
Plavchan P, Barclay T, Gagné J, Gao P, Cale B, Matzko W, Dragomir D, Quinn S, Feliz D, Stassun K, Crossfield IJM, Berardo DA, Latham DW, Tieu B, Anglada-Escudé G, Ricker G, Vanderspek R, Seager S, Winn JN, Jenkins JM, Rinehart S, Krishnamurthy A, Dynes S, Doty J, Adams F, Afanasev DA, Beichman C, Bottom M, Bowler BP, Brinkworth C, Brown CJ, Cancino A, Ciardi DR, Clampin M, Clark JT, Collins K, Davison C, Foreman-Mackey D, Furlan E, Gaidos EJ, Geneser C, Giddens F, Gilbert E, Hall R, Hellier C, Henry T, Horner J, Howard AW, Huang C, Huber J, Kane SR, Kenworthy M, Kielkopf J, Kipping D, Klenke C, Kruse E, Latouf N, Lowrance P, Mennesson B, Mengel M, Mills SM, Morton T, Narita N, Newton E, Nishimoto A, Okumura J, Palle E, Pepper J, Quintana EV, Roberge A, Roccatagliata V, Schlieder JE, Tanner A, Teske J, Tinney CG, Vanderburg A, von Braun K, Walp B, Wang J, Wang SX, Weigand D, White R, Wittenmyer RA, Wright DJ, Youngblood A, Zhang H, Zilberman P.   +86 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Haro 5-2: A New Pre-main-sequence Quadruple Stellar System

The Astronomical Journal
We have discovered that the H α emission-line star Haro 5-2, located in the 3–6 Myr old Ori OB1b association, is a young quadruple system. The system has a 2+2 configuration, with an outer separation of 2.″6 and with resolved subarcsecond inner binary ...
Bo Reipurth, C. Briceño, T. R. Geballe, C. Baranec, S. Mikkola, A. M. Cody, M. S. Connelley, C. Flores, B. A. Skiff, J. D. Armstrong, N. M. Law, R. Riddle   +11 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Tracing early stellar evolution with asteroseismology: pre-main sequence stars in NGC 2264

EPJ Web of Conferences, 2015
Asteroseismology has been proven to be a successful tool to unravel details of the internal structure for different types of stars in various stages of their main sequence and post-main sequence evolution.
Zwintz Konstanze, Fossati Luca, Ryabchikova Tatiana, Guenther David, Aerts Conny   +4 more
doaj   +1 more source