Results 91 to 100 of about 14,388,284 (282)

Age-related observations of low mass pre-main and young main sequence stars [PDF]

, 2009
This overview summarizes the age dating methods available for young sub-solar mass stars. Pre-main sequence age diagnostics include the Hertzsprung-Russell (HR) diagram, spectroscopic surface gravity indicators, and lithium depletion; asteroseismology is
Hillenbrand, Lynne A.
core  

Pre main sequence stars as UV sources for the World Space Observatory-UV mission

, 2011
Pre-main sequence stars are bright UV (UV) sources compared with their main sequence analogues. The source of this excess is the high energy processes associated with the physics of accretion/outflow during early stellar evolution.
Sergei A. Lamzin, Gómez De Castro, Ana Inés, Lamzin, Sergei A., Ana I. Gomez de Castro   +3 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Asteroseismology of pre-main sequence stars [PDF]

Communications in Asteroseismology, 2009
Intermediate-mass pre-main sequence (PMS) stars cross the instability region on their way to the main sequence and can become pulsationally unstable. The δ Scuti-like PMS pulsators populate the same area in the Hertzsprung-Russell (HR) diagram as the classical δ Scuti stars.
openaire   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

SMA 200–400 GHz Survey for Dust Properties in the Icy Class II Disks in the Taurus Molecular Cloud

The Astrophysical Journal Supplement Series
We present a new Submillimeter Array survey of 47 Class II sources in the Taurus–Auriga region. Our observations made 12 independent samples of flux densities over the 200–400 GHz frequency range.
Chia-Ying Chung, Sean M. Andrews, Mark A. Gurwell, Melvyn Wright, Feng Long, Wenrui Xu, Hauyu Baobab Liu   +6 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Simultaneous Far-ultraviolet and Near-ultraviolet Observations of T Tauri Stars with UVIT/AstroSat: Probing the Accretion Process in Young Stars

The Astrophysical Journal
We present results from simultaneous far-ultraviolet (FUV) and near-ultraviolet (NUV) observations of T Tauri stars (TTSs) in the Taurus molecular cloud with UVIT/AstroSat. This is the very first UVIT study of TTSs.
Prasanta K. Nayak, Mayank Narang, P. Manoj, Uma Gorti, Annapurni Subramaniam, Nayana George, Chayan Mondal   +6 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source