Results 121 to 130 of about 241,576 (378)

Abundance anomalies in pre-main-sequence stars: Stellar evolution models with mass loss [PDF]

, 2003
The effects of atomic diffusion on internal and surface abundances of A and F pre-main-sequence stars with mass loss are studied in order to determine at what age the effects materialize, as well as to further understand the processes at play in HAeBe ...
Vick, M., Michaud, G., Richer, J., Richard, O.   +3 more
core   +4 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Two Young Eclipsing Binaries in Orion with Temperatures and Radii Affected by Spots and Third Bodies

The Astronomical Journal
In this work we present a model of two young eclipsing binaries in the Orion complex. Both heavily spotted, they present radii and temperatures that are in disagreement with the predictions of standard stellar models.
Marina Kounkel, Keivan G. Stassun
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The Nature of X-Rays from Young Stellar Objects in the Orion Nebula Cluster—A Chandra HETGS Legacy Project

The Astrophysical Journal
The Orion Nebula Cluster (ONC) is the closest site of very young (∼1 Myr) massive star formation The ONC hosts more than 1600 young and X-ray bright stars with masses ranging from ∼0.1–35 M _⊙ .
Norbert S. Schulz, David P. Huenemoerder, David A. Principe, Marc Gagne, Hans Moritz Günther, Joel Kastner, Joy Nichols, Andrew Pollock, Thomas Preibisch, Paola Testa, Fabio Reale, Fabio Favata, Claude R. Canizares   +12 more
doaj   +1 more source

Pre-main sequence stars in the Cepheus flare region

, 2009
We present results of optical spectroscopic and BVR_CI_C photometric observations of 77 pre-main sequence (PMS) stars in the Cepheus flare region. A total of 64 of these are newly confirmed PMS stars, originally selected from various published candidate ...
Bally, Balog, Barrado y Navascués, Beltrán, Berkhuijsen, Cieza, Cutri, D'Alessio, Dahm, Dobashi, Dullemond, Eiroa, Eiroa, Eredics, Eric E. Mamajek, Evans, Friedemann, Glass, Gullbring, Gutermuth, Gutermuth, Gutermuth, Herbig, Herczeg, Hester, Jaschek, Joint IRAS Science W. G., Kirk, Kun, Kun, Kun, Kun, Lada, Lee, Lee, Meehan, Miranda, Miranda, Moshir, Muzerolle, Mária Kun, Ogura, Padgett, Page, Palla, Preibisch, Reipurth, Robert A. Gutermuth, Rosino, Scott J. Kenyon, Semkov, Semkov, Shevchenko, Simon, Spoelstra, Straizys, Yonekura, Zdanavičius, Zoltán Balog, Ábrahám   +59 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Characterizing the Low-mass Pre-main-sequence Population in the Low-metallicity Star-forming Region Dolidze 25 Using VLT-MUSE

The Astrophysical Journal
The metallicity of the star-forming environment is a fundamental parameter shaping the evolution of protoplanetary disks and the formation of planetary systems, yet its influence remains poorly constrained.
Mizna Ashraf, Jessy Jose, Gregory J. Herczeg, Min Fang, Varsha Ramachandran, Carlo F. Manara, Christian Schneider, Megan Reiter, Kiran Kumar Sunil   +8 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Spectral Variability of Herbig Ae Star V1295, Aquila

Galaxies
This article presents the results of long-term spectral studies of the unusual Herbig Ae star V1295 Aql. The variability in the spectrophotometric parameters of the emission and absorption components of the hydrogen lines Hα, Hβ, and D Na I—and of ...
Hemayil Adigozalzade, Silva Jarvinen, Swetlana Hubrig, Ulviyya Bashirova, Nariman Ismailov   +4 more
doaj   +1 more source