Results 101 to 110 of about 216,058 (291)

Radial differential rotation leading to dipole collapse in pre-main-sequence stars

Astronomy & Astrophysics
Context. Despite significant progress in the observational characterization of stellar magnetic fields, the physical processes that govern their intensity and topology, which could certainly result from their formation history, remain poorly understood ...
Guseva A., Manchon L., Petitdemange L., Pinçon C.   +3 more
doaj   +1 more source

A Census of B[e] Supergiants

Galaxies, 2019
Stellar evolution theory is most uncertain for massive stars. For reliable predictions of the evolution of massive stars and their final fate, solid constraints on the physical parameters, and their changes along the evolution and in different ...
Michaela Kraus
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Effect of Time-varying X-Ray Emission from Stellar Flares on the Ionization of Protoplanetary Disks

The Astrophysical Journal
X-rays have significant impacts on cold, weakly ionized protoplanetary disks by increasing the ionization rate and driving chemical reactions. Stellar flares are explosions that emit intense X-rays and are the unique source of hard X-rays with an energy ...
Haruka Washinoue, Shinsuke Takasao, Kenji Furuya   +2 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

The gas temperature in flaring disks around pre-main sequence stars

, 2004
A model is presented which calculates the gas temperature and chemistry in the surface layers of flaring circumstellar disks using a code developed for photon-dominated regions. Special attention is given to the influence of dust settling.
Aikawa, Aikawa, B. Jonkheid, Bakes, Bary, Bell, Bergin, Berruyer, Black, Boss, Brittain, Burke, Chiang, Costa, D'Alessio, D'Alessio, Dartois, Draine, Dullemond, Dutrey, Dutrey, E. F. van Dishoeck, F. G. A. Faas, Flower, Flower, G.-J. van Zadelhoff, Hayes, Herczeg, Hogerheijde, Hollenbach, Jansen, Jaquet, Kamp, Kamp, Kastner, Kenyon, Koerner, Launay, Launay, Le Bourlot, Li, Lissauer, Mannings, Markwick, Meeus, Miyake, Najita, Qi, Schröder, Shu, Shuping, Stepinski, Thi, Throop, Tielens, van Dishoeck, van Zadelhoff, van Zadelhoff, Warin, Weidenschilling, Willacy   +60 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Inactive Longitude and Superflare in the Active Single-lined Pre-main-sequence Binary V2279 Cyg

The Astrophysical Journal
Young, solar-like stars in the pre-main-sequence (PMS) stage exhibit vigorous magnetic activity that significantly influences their circumstellar environments and the processes of planetary formation and evolution.
Xueying Hu, Tianqi Cang, Jian-Ning Fu, Xuan Wang, Keyu Xing, Haotian Wang, Pascal Petit, Jiaxin Wang, Yong Yang, He Zhao   +9 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source