Results 81 to 90 of about 216,058 (291)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Two Young Eclipsing Binaries in Orion with Temperatures and Radii Affected by Spots and Third Bodies

The Astronomical Journal
In this work we present a model of two young eclipsing binaries in the Orion complex. Both heavily spotted, they present radii and temperatures that are in disagreement with the predictions of standard stellar models.
Marina Kounkel, Keivan G. Stassun
doaj   +1 more source

The Effects of Stellar Wind, Rotation Velocity, and Overshoot Parameters on The Evolution of Massive Stars using MESA: Case Study of MPG 324, MPG 355, MPG 682

Spektra: Jurnal Fisika dan Aplikasinya
Massive stars (over 8 solar masses) undergo intricate cosmic journeys. Their evolution, shaped by parameters like stellar wind, rotation velocity, and overshoot, generally includes the pre-main sequence, main sequence, and post-main sequence phases.
Alin Hafizhah Adira, Aprilia
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dynamical masses of young stellar objects with the VLBA: DYNAMO-VLBA

Astronomy & Astrophysics
We present results from a multi-epoch Very Long Baseline Array (VLBA) survey of compact radio sources in the Orion complex, conducted within both the DYNAMO–VLBA and GOBELINS projects.
Dzib Sergio A., Ordóñez-Toro Jazmín, Loinard Laurent, Kounkel Marina, Ortiz-León Gisela N., Galli Phillip A. B., Rodríguez Luis F., Mioduszewski Amy J., Masqué Josep M., O’Kelly Eoin, Forbrich Jan, Moo-Herrera Karla   +11 more
doaj   +3 more sources

The Nature of X-Rays from Young Stellar Objects in the Orion Nebula Cluster—A Chandra HETGS Legacy Project

The Astrophysical Journal
The Orion Nebula Cluster (ONC) is the closest site of very young (∼1 Myr) massive star formation The ONC hosts more than 1600 young and X-ray bright stars with masses ranging from ∼0.1–35 M _⊙ .
Norbert S. Schulz, David P. Huenemoerder, David A. Principe, Marc Gagne, Hans Moritz Günther, Joel Kastner, Joy Nichols, Andrew Pollock, Thomas Preibisch, Paola Testa, Fabio Reale, Fabio Favata, Claude R. Canizares   +12 more
doaj   +1 more source

Testing evolutionary tracks of Pre-Main Sequence stars: the case of HD113449 [PDF]

, 2008
Evolutionary tracks are of key importance for the understanding of star formation. Unfortunately, tracks published by various groups differ so that it is fundamental to have observational tests. In order to do this, we intend to measure the masses of the
E. Covino, E. W. Guenther, Eric Stempels, F. Cusano, J. M. Alcalà, M. Esposito, M. Mundt   +6 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

X-Ray Evolution of Young Stars: Early Dimming and Coronal Softening in Solar-mass Stars with Implications for Planetary Atmospheres

The Astrophysical Journal
X-ray and ultraviolet (XUV) emission from young stars plays a critical role in shaping the evolution of planetary atmospheres and the conditions for habitability.
Konstantin V. Getman, Eric D. Feigelson, Vladimir S. Airapetian, Gordon P. Garmire   +3 more
doaj   +1 more source

Polarization: A Method to Reveal the True Nature of the Dusty S-Cluster Object (DSO/G2)

Galaxies, 2018
There have been different scenarios describing the nature of a dusty source, noted as Dusty S-cluster Object (DSO) or G2, orbiting around the Galactic centre super-massive black hole.
Banafsheh Shahzamanian, Andreas Eckart, Michal Zajacek, Monica Valencia-S., Nadeen B. Sabha   +4 more
doaj   +1 more source