Results 71 to 80 of about 22,441 (303)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The mass function of pre-main sequence stars
ASTRONOMY AT THE EPOCH OF MULTIMESSENGER STUDIES. Proceedings of the VAK-2021 conference, Aug 23–28, 2021, 2022 The information about 26 pre-man sequence (PMS) binary stars and 34 stars with protoplanetary disks with well determinedmasses from the observations is collected. We constructed the mass distribution of PMS stars and approximated it with apower law dN ∼M −γ dM .
A. Dudorov, O. Eretnova
openaire +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
The potential of space observations for pulsating pre-main sequence stars
EPJ Web of Conferences, 2017 The first asteroseismic studies of pre-main sequence (pre-MS) pulsators have been conducted based on data from the space telescopes MOST and CoRoT with typical time bases of less than 40 days.
Zwintz Konstanze
doaj +1 more source
Space-based photometry reveals regular high-frequency patterns in many young Scuti stars. These pulsations provide a powerful means of inferring stellar properties, particularly ages, for young Scuti stars for which traditional age-dating methods are ...
Murphy, Simon J. +2 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Active Young Stars in the LAMOST–Kepler Survey
The Astrophysical Journal Supplement SeriesIn the early stages of their lives, young stars harbor diverse processes exhibiting strong signatures, making them ideal targets for investigating stellar accretion, dynamo actions, and exoplanet formation.
FuKun Xu, Shenghong Gu, Yue Xiang
doaj +1 more source
Are pre-main-sequence stars older than we thought?
, 2009 We fit the colour–magnitude diagrams of stars between the zero-age main-sequence and terminal-age main sequence in young clusters and associations. The ages we derive are a factor of 1.5–2 longer than the commonly used ages for these regions, which are ...
Tim Naylor (21824576)
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source