Results 71 to 80 of about 12,001 (263)

The Pre--Main-Sequence of A-type stars

, 2004
Young A-type stars in the pre--main-sequence (PMS) evolutionary phase are particularly interesting objects since they cover the mass range (1.5-4 solar ma sses) which is most sensitive to the internal conditions inherited during the protostellar phase. In particular, they undergo a process of thermal relaxation from which they emerge as fully radiative
Marconi, Marcella, Palla, Francesco
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Characterizing the Low-mass Pre-main-sequence Population in the Low-metallicity Star-forming Region Dolidze 25 Using VLT-MUSE

The Astrophysical Journal
The metallicity of the star-forming environment is a fundamental parameter shaping the evolution of protoplanetary disks and the formation of planetary systems, yet its influence remains poorly constrained.
Mizna Ashraf, Jessy Jose, Gregory J. Herczeg, Min Fang, Varsha Ramachandran, Carlo F. Manara, Christian Schneider, Megan Reiter, Kiran Kumar Sunil   +8 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

X-Ray Evolution of Young Stars: Early Dimming and Coronal Softening in Solar-mass Stars with Implications for Planetary Atmospheres

The Astrophysical Journal
X-ray and ultraviolet (XUV) emission from young stars plays a critical role in shaping the evolution of planetary atmospheres and the conditions for habitability.
Konstantin V. Getman, Eric D. Feigelson, Vladimir S. Airapetian, Gordon P. Garmire   +3 more
doaj   +1 more source

Spectral Variability of Herbig Ae Star V1295, Aquila

Galaxies
This article presents the results of long-term spectral studies of the unusual Herbig Ae star V1295 Aql. The variability in the spectrophotometric parameters of the emission and absorption components of the hydrogen lines Hα, Hβ, and D Na I—and of ...
Hemayil Adigozalzade, Silva Jarvinen, Swetlana Hubrig, Ulviyya Bashirova, Nariman Ismailov   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Radial differential rotation leading to dipole collapse in pre-main-sequence stars

Astronomy & Astrophysics
Context. Despite significant progress in the observational characterization of stellar magnetic fields, the physical processes that govern their intensity and topology, which could certainly result from their formation history, remain poorly understood ...
Guseva A., Manchon L., Petitdemange L., Pinçon C.   +3 more
doaj   +1 more source