Results 41 to 50 of about 12,001 (263)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Pulsation in pre-main sequence stars [PDF]
Proceedings of the International Astronomical Union, 2015 AbstractAsteroseismology has been proven to be a successful tool to unravel details of the internal structure for different types of stars in various stages of evolution well after birth. We can now show that it has similar power for pre-main sequence (pre-MS) objects.
openaire +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An HST Study of the Substellar Population of NGC 2024
The Astrophysical Journal, 2023 We performed an HST/WFC3-IR imaging survey of the young stellar cluster NGC 2024 in three filters probing the 1.4 μ m H _2 O absorption feature, characteristic of the population of low-mass and substellar-mass objects down to a few Jupiter masses.
Massimo Robberto +8 more
doaj +1 more source
Asteroseismology of pre-main sequence stars [PDF]
Communications in Asteroseismology, 2009 Intermediate-mass pre-main sequence (PMS) stars cross the instability region on their way to the main sequence and can become pulsationally unstable. The δ Scuti-like PMS pulsators populate the same area in the Hertzsprung-Russell (HR) diagram as the classical δ Scuti stars.
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The pre-main-sequence star IP Persei [PDF]
Astronomy & Astrophysics, 2001 We present the results of high- and low-resolution spectroscopic and broadband multicolour photometric observations of the emission-line A-type star IP Per. Significant variations of the Balmer line profiles and near-IR brightness are detected.
A. S. Miroshnichenko +6 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The Astrophysical JournalWe present results from simultaneous far-ultraviolet (FUV) and near-ultraviolet (NUV) observations of T Tauri stars (TTSs) in the Taurus molecular cloud with UVIT/AstroSat. This is the very first UVIT study of TTSs.
Prasanta K. Nayak +6 more
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source