Results 101 to 110 of about 270,676 (398)

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Towards an analysis of in vitro RNA binding capabilities of essential splicing factor U2AF [PDF]

, 2011
U2 auxiliary factor (U2AF) is an important component of the eukaryotic spliceosome and is essential for pre-mRNA splicing in Schizosaccharomyces pombe. Studies have shown that RNA binding is required for U2AF’s role in spliceosome assembly. We have found
Christy, Alexis
core   +2 more sources

Live-Cell Visualization of Pre-mRNA Splicing with Single-Molecule Sensitivity [PDF]

, 2013
SummaryRemoval of introns from pre-messenger RNAs (pre-mRNAs) via splicing provides a versatile means of genetic regulation that is often disrupted in human diseases. To decipher how splicing occurs in real time, we directly examined with single-molecule
Carmo-Fonseca, Maria, Carvalho, Célia, Kirchhausen, Tomas, Martin, Robert M., Rino, José   +4 more
core   +2 more sources

Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role

Nature Communications, 2018
Dysregulation of pre-mRNA alternative splicing (AS) is closely associated with cancers. However, the relationships between the AS and classic oncogenes/tumor suppressors are largely unknown.
Shao-Ming Shen, Yan Ji, Cheng Zhang, Shuang-Shu Dong, Shuo Yang, Zhong Xiong, Meng-Kai Ge, Yun Yu, L. Xia, Meng Guo, Jin Cheng, Jun-ling Liu, Jian-Xiu Yu, Guoqiang Chen   +13 more
semanticscholar   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing [PDF]

, 2004
Pre-mRNA processing is an important mechanism for globally modifying cellular protein composition during tumorigenesis. To understand this process during lung cancer, expression of two key pre-mRNA alternative splicing factors was compared in a mouse ...
Cosper, P. (P.F.), Dwyer-Nield, L. (L.D.), Malkinson, A.M. (Alvin M.), Meyer, A.M. (Amy M.), Montuenga-Badia, L.M. (Luis M.), Pino, I. (Irene), Pio, R. (Rubén), Port, J.D. (J. David), Zerbe, L.K. (Laura K.)   +8 more
core   +1 more source

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged.

Genes & Development, 2010
Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of gene control in humans. It provides cells with the opportunity to create protein isoforms of differing, even opposing, functions from a single gene.
Charles J. David, J. Manley
semanticscholar   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

H3K36 Methylation and the Chromodomain Protein Eaf3 Are Required for Proper Cotranscriptional Spliceosome Assembly

Cell Reports, 2019
Summary: In the eukaryotic cell, spliceosomes assemble onto pre-mRNA cotranscriptionally. Spliceosome assembly takes place in the context of the chromatin environment, suggesting that the state of the chromatin may affect splicing.
Calvin S. Leung, Stephen M. Douglass, Marco Morselli, Matthew B. Obusan, Marat S. Pavlyukov, Matteo Pellegrini, Tracy L. Johnson   +6 more
doaj  

Co-transcriptional degradation of aberrant pre-mRNA by Xrn2 [PDF]

, 2012
Eukaryotic protein-coding genes are transcribed as pre-mRNAs that are matured by capping, splicing and cleavage and polyadenylation. Although human pre-mRNAs can be long and complex, containing multiple introns and many alternative processing sites, they
Adams, Alastair Kerr, Andrulis, Ashe, Ballarino, Bentley, Bousquet-Antonelli, Brody, Buratowski, Corden, Core, Corrionero, Custodio, de Almeida, Dye, Dye, Dye, Dziembowski, Eberle, Egecioglu, El Hage, Glover-Cutter, Gromak, Grousl, Hessle, Hilleren, Hilleren, Jiao, Jimeno-Gonzalez, Kaida, Kaida, Kaneko, Kawauchi, Kim, Kim, Lebreton, Lee Davidson, Listerman, Liu, Luke, Mapendano, Martins, McCracken, Mischo, Moore, Morlando, Ozsolak, Roybal, Schmid, Schmidt, Schneider, Schwer, Song, Steven West, Stevens, Torchet, van Dijk, Wang, Wang, West, West, West, West, Wuarin   +63 more
core   +2 more sources