Results 111 to 120 of about 270,676 (398)
Nature Communications, 2015 The phytohormone abscisic acid (ABA) is important for growth, development and stress responses in plants. Recent research has identified ABA receptors and signalling components that regulate seed germination and stomatal closure.
X. Zhan +11 more
semanticscholar +1 more source
RNA catalyses nuclear pre-mRNA splicing [PDF]
Nature, 2013 In nuclear pre-messenger RNA splicing, introns are excised by the spliceosome, a dynamic machine composed of both proteins and small nuclear RNAs (snRNAs). Over thirty years ago, after the discovery of self-splicing group II intron RNAs, the snRNAs were proposed to catalyse splicing.
Thaddeus Novak +8 more
openaire +3 more sources
Advanced Engineering Materials, EarlyView.Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source
Theory on the Coupled Stochastic Dynamics of Transcription and Splice-Site Recognition [PDF]
, 2012 Eukaryotic genes are typically split into exons that need to be spliced together to form the mature mRNA. The splicing process depends on the dynamics and interactions among transcription by the RNA polymerase II complex (RNAPII) and the spliceosomal ...
Kreiman, Gabriel, Murugan, Rajamanickam
core +3 more sources
Beyond Transcription: Roles of Transcription Factors in Pre-mRNA Splicing.
Chemical Reviews, 2017 Whereas individual steps of protein-coding gene expression in eukaryotes can be studied in isolation in vitro, it has become clear that these steps are intimately connected within cells.
Xavier Rambout, F. Dequiedt, L. Maquat
semanticscholar +1 more source
Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo
Advanced Healthcare Materials, EarlyView.This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla +16 more
wiley +1 more source
PLoS ONE, 2014 Most human pre-mRNAs contain introns that are removed by splicing. Such a complex process needs strict control and regulation in order to prevent the expression of aberrant or unprocessed transcripts.
Anne Hett, Steven West
doaj +1 more source
The role of the Ou element in SL1 trans-splicing in C. elegans nematodes [PDF]
, 2011 The nematode C. elegans exhibits SL1 trans-splicing, a unique form of pre-mRNA Processing seen in a variety of lower metazoans. In C. elegans, there are two types of trans-spliced leader that are added onto the 5\u27 end of trans-spliced pre-mRNA: SL2 ...
Gallegos, Jenna
core +2 more sources
Nucleic Acids Research, 2006 Besides linear RNAs, pre-mRNA splicing generates three forms of RNAs: lariat introns, Y-structure introns from trans-splicing, and circular exons through exon skipping.
H. Suzuki +5 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.This study presents a multiphasic bile duct construct composed of biocompatible materials and cells, featuring an inner layer that supports biliary epithelium growth, a middle layer providing mechanical strength, and an outer cell‐permissive layer designed to support future in vivo integration.
Mattia Pasqua +9 more
wiley +1 more source