Results 121 to 130 of about 270,676 (398)

CRH-R splicing in estrogen-sensitive breast cancer [PDF]

, 2014
Alternative pre-mRNA splicing contributes in the acquired genomic alterations involved in the pathobiology of cancer development and progression.1 In normal biological systems, this mechanism allows protein complexity and diversity by increasing gene ...
Grammatopoulos, Dimitris
core   +1 more source

Regulation of pre-mRNA splicing in metazoa

Current Opinion in Genetics & Development, 1997
Recent studies have identified additional cis-acting sequence elements that can either positively or negatively regulate pre-mRNA splicing. Trans-acting protein factors involved in tissue-specific splicing regulation have been characterized. The functions of splicing factors have been explored in vivo and certain splicing factors have been demonstrated
Jin Wang, James L. Manley
openaire   +3 more sources

Genetic Engineering Methods in Primary T Cells

Advanced Therapeutics, EarlyView.
Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley   +1 more source

The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture

eLife, 2017
Production of most eukaryotic mRNAs requires splicing of introns from pre-mRNA. The splicing reaction requires definition of splice sites, which are initially recognized in either intron-spanning (‘intron definition’) or exon-spanning (‘exon definition’)
A. Pai, Telmo Henriques, Kayla McCue, Adam B. Burkholder, K. Adelman, C. Burge   +5 more
semanticscholar   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Inhibition of pre-mRNA splicing by a synthetic Blom7α-interacting small RNA.

PLoS ONE, 2012
Originally the novel protein Blom7α was identified as novel pre-mRNA splicing factor that interacts with SNEV(Prp19/Pso4), an essential protein involved in extension of human endothelial cell life span, DNA damage repair, the ubiquitin-proteasome system,
Marlies Löscher, Markus Schosserer, Eric Dausse, Kiseok Lee, Paul Ajuh, Regina Grillari-Voglauer, Angus I Lamond, Jean-Jacques Toulmé, Johannes Grillari, Johannes Grillari   +9 more
doaj   +1 more source

Alternative RNA splicing: contribution to pain and potential therapeutic strategy [PDF]

, 2016
Since the sequencing of metazoan genomes began, it has become clear that the number of expressed proteins far exceeds the number of genes. It is now estimated that greater up to 98% of human genes give rise to multiple proteins through alternative pre ...
Abbadie, Akopian, Altier, Alvarez, Alvarez de la Rosa, Amara, Andrade, Ataman, Bagal, Bar, Barker, Bassler, Bateson, Beazley-Long, Bennett, Benoliel, Beqollari, Bilson, Blaustein, Bo, Bockaert, Bolan, Bonomi, Bowersox, Brandle, Buraei, Burnstock, Calignano, Castiglioni, Caterina, Chang, Chen, Chen, Chessell, Cizkova, Connor, Deval, Enna, Eswarappa, Fang, Fang, Fedorov, Fritschy, Fukuhara, Gammons, Gaunitz, Geib, Ghosh, Giunti, Graziewicz, Hansen, Harper, Hobom, Hong, Huh, Hulse, Hulse, Hulse, Jarecki, Jiang, Just, Kaczmarek-Hajek, Kerr, Kim, Kole, Lana, Lee, Levine, Licatalosi, Lin, Lipscombe, Liu, Lu, Lu, Lucy F. Donaldson, Lujan, Luque, Markovic, Matsuoka, McKernan, Mich, Mittendorf, Moreno Davila, Mourich, Nakae, Nicholas Beazley-Long, Noel, Pan, Pasternak, Pasternak, Patel, Pohl, Raymond, Ryberg, Rycroft, Sagar, Sasabe, Sato, Schirmeyer, Schuller, Schumacher, Schumacher, Smith, Soret, Sussman, Swayne, Tanowitz, Terashima, Townsend-Nicholson, Vazquez, Veale, Viguier, Wang, Ward, Westenbroek, Whiting, Wotherspoon, Xu, Xu, Yalcin, Yokoyama, Yu, Zhang, Zhang, Zheng, Zhou   +125 more
core   +3 more sources

METTL14‐Mediated M6A Modification of LINC01094 Induces Glucose Metabolic Reprogramming in Breast Cancer by Recruiting the PKM2/JMJD5 Complex

Advanced Science, EarlyView.
METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang, Zhaoxin Gao, Ruinan Zhao, Pan Zhou, Jingxi Chen, Hui Zhang, Yawen Wang, Wenjie Zhu, Peng Gao   +8 more
wiley   +1 more source

Bcl-x Pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia [PDF]

, 2012
The bcl-x gene appears to play a critical role in regulating apoptosis in the developing and mature central nervous system (CNS) and following CNS injury. Two isoforms of Bcl-x are produced as a result of alternative pre-mRNA splicing: Bcl-x(L) (the long
Ford, Andria L, Gonzales, Ernesto, Holtzman, David M, Lee, Jin-Moo, Lee, Kuang-Yung, West, Tim, Xiao, Qingli, Xu, Jan, Yan, Ping   +8 more
core   +2 more sources

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, EarlyView.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source