Results 211 to 220 of about 270,676 (398)

Pre-mRNA splicing-associated diseases and therapies. [PDF]

RNA Biol, 2023
Love SL, Emerson JD, Koide K, Hoskins AA.   +3 more
europepmc   +1 more source

Higher structure of nucleic acids and their biological activity. Signals and their recognition for pre-mRNA splicing.

, 1987
Yoshiro Shimura
openalex   +2 more sources

Editing of pre-mRNAs can occur before cis- and trans-splicing in Petunia mitochondria. [PDF]

, 1991
C A Sutton, Patricia L. Conklin, Kirn D Pruitt, Maureen R. Hanson   +3 more
openalex   +1 more source

EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways

Advanced Science, EarlyView.
EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen, Ying Li, Yan Yu, Mingze Cai, Hao Li, Minghe Huang, Guochao Yang, Jiageng Guo, Huailin Wang, Zhihong Song, Wei Shen, Huihui Jiang, Haitao Wu   +12 more
wiley   +1 more source

Targeting pre-mRNA splicing in cancers: roles, inhibitors, and therapeutic opportunities. [PDF]

Front Oncol, 2023
Araki S, Ohori M, Yugami M.
europepmc   +1 more source

The interaction between the first and last intron nucleotides in the second step of pre-mRNA splicing is independent of other conserved intron nucleotides [PDF]

, 1994
Brian L. Ruis, Wendy J. Kivens, Paul G. Siliciano   +2 more
openalex   +1 more source

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

Advanced Science, EarlyView.
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen, Fugui Zhang, Yifei Xiao, Xuejun Jiang, Zhiqian Yan, Jinyi Wang, Xiting Lv, Jialu Cui, Linna Ha, Hui Chen, Yongkang Dang, Zifei Qin, Jing Yang, Baojian Wu   +13 more
wiley   +1 more source

CPSF3 Promotes Pre-mRNA Splicing and Prevents CircRNA Cyclization in Hepatocellular Carcinoma. [PDF]

Cancers (Basel), 2023
Huang Y, Ji H, Dong J, Wang X, He Z, Cheng Z, Zhu Q.   +6 more
europepmc   +1 more source

Associations between distinct pre-mRNA splicing components and the cell nucleus. [PDF]

, 1991
David L. Spector, Xiang‐Dong Fu, Tom Maniatis   +2 more
openalex   +1 more source

Single‐Cell Transcriptome Profiling Reveals Conserved IFNγ‐IL8 Signaling‐Induced Antibacterial Neutrophil States during Bacterial Infection

Advanced Science, EarlyView.
SummaryThis study constructs a single‐cell immune atlas of Nile tilapia across multiple time points during Streptococcus agalactiae infection, revealing dynamic immune cell responses and subtype transitions. It identifies a conserved IFNr‐STAT1‐IL8 axis driving il8+ neutrophils activation and antibacterial function, supported by cross‐species ...
Xue Zhai, Minghao Zhang, Kang Li, Wei Li, Xiaolong Li, Wa Gao, Zhaosheng Sun, Dan Huang, Songqian Huang, Mingli Liu, Zhichao Wu, Jun Zou, Liangbiao Chen, Jialong Yang, Peng Hu   +14 more
wiley   +1 more source