Results 211 to 220 of about 211,616 (238)
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1997
Abstract The formation of a mature mRNA from a primary transcript generally requires excision of intervening sequences (introns) with the subsequent joining together (splicing) of exons. The general splicing reaction of metazoan intrans has been well characterized and involves a two-step process, which occurs in a large ribonuclear ...
Yung-chih wang +2 more
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Abstract The formation of a mature mRNA from a primary transcript generally requires excision of intervening sequences (introns) with the subsequent joining together (splicing) of exons. The general splicing reaction of metazoan intrans has been well characterized and involves a two-step process, which occurs in a large ribonuclear ...
Yung-chih wang +2 more
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Pre-mRNA splicing in higher plants
Trends in Plant Science, 2000Most plant mRNAs are synthesized as precursors containing one or more intervening sequences (introns) that are removed during the process of splicing. The basic mechanism of spliceosome assembly and intron excision is similar in all eukaryotes. However, the recognition of introns in plants has some unique features, which distinguishes it from the ...
Z J, Lorković +3 more
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1995
The biogenesis of mature, functional mRNA in eukaryotes often requires the precise excision of noncoding, intervening sequences (i.e., introns) which are present in the precursor mRNA (pre-mRNA) molecule and subsequent ligation of the flanking, functional sequences (i.e., exons).
C. L. Will, P. Fabrizio, R. Lührmann
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The biogenesis of mature, functional mRNA in eukaryotes often requires the precise excision of noncoding, intervening sequences (i.e., introns) which are present in the precursor mRNA (pre-mRNA) molecule and subsequent ligation of the flanking, functional sequences (i.e., exons).
C. L. Will, P. Fabrizio, R. Lührmann
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2017
The splicing of precursor messenger RNA (pre-mRNA) requires the precise cleavage and formation of multiple phosphodiester bonds in nascent pre-mRNA polymers in order to produce a protein coding message that can be properly translated by the ribosome. Despite the precision of this process, the spliceosome maintains considerable flexibility to include ...
Matthew G. Woll +2 more
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The splicing of precursor messenger RNA (pre-mRNA) requires the precise cleavage and formation of multiple phosphodiester bonds in nascent pre-mRNA polymers in order to produce a protein coding message that can be properly translated by the ribosome. Despite the precision of this process, the spliceosome maintains considerable flexibility to include ...
Matthew G. Woll +2 more
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2000
Abstract In the late 1970s it was discovered that many eukaryotic genes are interrupted by non-coding sequences (intrans). Since then, various types of intrans have been identified, the mechanisms for their removal have been intensively researched, and the possible reasons for their existence have been the subject of much debate. Introns
Andrew E Mayes +2 more
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Abstract In the late 1970s it was discovered that many eukaryotic genes are interrupted by non-coding sequences (intrans). Since then, various types of intrans have been identified, the mechanisms for their removal have been intensively researched, and the possible reasons for their existence have been the subject of much debate. Introns
Andrew E Mayes +2 more
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Intron specificity in pre-mRNA splicing
Current Genetics, 2018The occurrence of spliceosomal introns in eukaryotic genomes is highly diverse and ranges from few introns in an organism to multiple introns per gene. Introns vary with respect to their lengths, strengths of splicing signals, and position in resident genes.
Shravan Kumar, Mishra, Poonam, Thakran
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Nuclear pre‐mRNA splicing in yeast
Yeast, 1989In this review I will summarize the genetic and biochemical approaches that have been used in Saccharomyces cerevisiae to determine the pathway of nuclear pre-mRNA splicing and to identify both cis- and trans-acting elements in these ...
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Protein functions in pre-mRNA splicing
Current Opinion in Cell Biology, 1997Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that potentially act as novel RNA helicases, GTPases, or protein isomerases. Novel protein-protein and protein-RNA interactions that are required for functional spliceosome formation have ...
C L, Will, R, Lührmann
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Structural basis of pre-mRNA splicing
Science, 2015Structure and function of the spliceosome When RNA is transcribed from DNA in the eukaryotic cell nucleus, the initial transcript includes noncoding introns that must be spliced out. This splicing is done by a complex macromolecular machine, the spliceosome, which comprises five small nuclear RNAs and more than ...
Jing, Hang +3 more
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Pre-mRNA splicing aberrations and cancer
Frontiers in Bioscience, 2008Splicing requires the accurate recognition of exonic sequences from the surrounding thousands of nucleotides of intronic sequence and is achieved by the coordinate interplay of splicing regulatory elements in genes and the trans-acting RNA and protein molecules to which they bind.
Pettigrew, C.A., Brown, M.A.
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