TTK promotes mitophagy by regulating ULK1 phosphorylation and pre-mRNA splicing to inhibit mitochondrial apoptosis in bladder cancer. [PDF]
Chen K +10 more
europepmc +1 more source
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source
SRSF10 regulates oligodendrocyte differentiation during mouse central nervous system development by modulating pre-mRNA splicing. [PDF]
Mu Y +8 more
europepmc +1 more source
ABSTRACT Honey bees (Apis mellifera) are vital pollinators in fruit‐producing agroecosystems like highbush blueberry (HBB) and cranberry (CRA). However, their health is threatened by multiple interacting stressors, including pesticides, pathogens, and nutritional changes.
Huan Zhong +25 more
wiley +1 more source
Npac Regulates Pre-mRNA Splicing in Mouse Embryonic Stem Cells. [PDF]
Qian Y, Ye Y, Zhang W, Wu Q.
europepmc +1 more source
Multiple Roles of Protamine Kinase SRPK1 and Phosphatase PP1γ in Sperm Development
ABSTRACT Protein phosphorylation regulates key events of male germ cell differentiation. In the testis, SRPK1 and PP1γ are involved in protamine phosphorylation and dephosphorylation, respectively, and their deregulation is linked to defective chromatin structure and male infertility.
Alberto de la Iglesia +7 more
wiley +1 more source
RNPS1 in PSAP complex controls periodic pre-mRNA splicing over the cell cycle. [PDF]
Fukumura K +6 more
europepmc +1 more source
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential, poor prognosis, and limited effective therapeutic options. In this study, we investigated the molecular mechanisms underlying the anticancer effects of the nucleolin (NCL)‐targeting DNA aptamer AS1411 using label‐free ...
Ha‐Song Bae +6 more
wiley +1 more source
The Rbfox1/LASR complex controls alternative pre-mRNA splicing by recognition of multipart RNA regulatory modules. [PDF]
Peyda P, Lin CH, Onwuzurike K, Black DL.
europepmc +1 more source
RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run +7 more
wiley +1 more source

