METTL5‐mediated 18S rRNA m6A modification enhances ribosome assembly and ABA response in Arabidopsis
iMeta, EarlyView.METTL5 catalyzes the N6‐methyladenosine (m6A) methylation at A1771 in 18S rRNA, a modification essential for its association with the ribosomal protein RPL24A, facilitating the assembly of 80S ribosome. This facilitates the translation of mRNAs encoding the detoxifying glutathione S‐transferase (GST) enzymes, thereby maintaining normal reactive oxygen ...
Ping Li +5 more
wiley +1 more source
Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre-mRNA Splicing as a Noncanonical Mechanism to Suppress Hepatocellular Carcinoma Metastasis. [PDF]
Adv Sci (Weinh)Nie D +11 more
europepmc +1 more source
Mitochondrial dysfunction: Related diseases, influencing factors, and detection
Interdisciplinary Medicine, EarlyView.Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li +9 more
wiley +1 more source
Pre-mRNA splicing in plants: characterization of Ser/Arg splicing factors.
, 1996 Sergiy Lopato +3 more
openalex +1 more source
New insights into applications of base editor in hereditary disorders
Interdisciplinary Medicine, EarlyView.Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai +8 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2015 S. Jimeno-González +6 more
semanticscholar +1 more source
Advanced single‐cell RNA sequencing in tumor immunology
Interdisciplinary Medicine, EarlyView.This review highlights the applications of advanced single‐cell RNA sequencing (scRNA‐seq) technologies in tumor immunology. It summarizes representative scRNA‐seq methods according to technical principles, with a focus on single‐cell T cell receptor sequencing. This review also discusses how scRNA‐seq is used to construct immune cell atlases of tumors,
Yilong Liu +8 more
wiley +1 more source
Male Reproduction in Spinal Muscular Atrophy (SMA) and the Potential Impact of Oral Survival of Motor Neuron 2 (SMN2) Pre-mRNA Splicing Modifiers. [PDF]
Neurol TherBar-Chama N +5 more
europepmc +1 more source
Functional analysis of the U5 snRNA loop 1in the second catalytic step of yeast pre-mRNA splicing
, 1998 Raymond T. O’Keefe, Andrew J. Newman
openalex +2 more sources
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Crohn's Disease (CD), an inflammatory bowel disorder, is influenced by genetic, immune, and environmental factors. The present study highlights the pioneering role of circular RNAs (circRNAs) in the etiology of CD, with a specific focus on hsa_circ_0005255 and its regulatory role.
Dong Liu, De‐Run Kong
wiley +1 more source