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Nuclear Pre-mRNA Splicing [PDF]
, 1995 The biogenesis of mature, functional mRNA in eukaryotes often requires the precise excision of noncoding, intervening sequences (i.e., introns) which are present in the precursor mRNA (pre-mRNA) molecule and subsequent ligation of the flanking, functional sequences (i.e., exons).
Cindy L. Will +2 more
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Current Opinion in Genetics & Development, 1994
Information from yeast and mammalian pre-mRNA splicing systems has advanced our understanding of the roles of protein factors in the early steps of spliceosome assembly. New results on the stereochemistry of nuclear pre-mRNA splicing and data on the transposition of Group II self-splicing introns in vivo have fuelled the long-running debate on the ...
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Information from yeast and mammalian pre-mRNA splicing systems has advanced our understanding of the roles of protein factors in the early steps of spliceosome assembly. New results on the stereochemistry of nuclear pre-mRNA splicing and data on the transposition of Group II self-splicing introns in vivo have fuelled the long-running debate on the ...
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Intron specificity in pre-mRNA splicing
Current Genetics, 2018The occurrence of spliceosomal introns in eukaryotic genomes is highly diverse and ranges from few introns in an organism to multiple introns per gene. Introns vary with respect to their lengths, strengths of splicing signals, and position in resident genes.
S. Mishra, Poonam Thakran
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The structure and function of proteins involved in mammalian pre-mRNA splicing.
Annual Review of Biochemistry, 1996Intervening sequences are removed from nuclear pre-mRNAs in a well-defined multi-step pathway. Small nuclear ribonucleoprotein particles (snRNPs) and numerous protein factors are essential for the formation of the active spliceosome in which intron ...
A. Krämer
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Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences, 1992
SynopsisPre-messenger RNA (pre-mRNA) splicing or the removal of introns from pre-mRNA transcripts is a key process in the maturation of mRNA. This process requires the assembly of a large complex of RNA and protein molecules, called the splicosome, on the pre-mRNA transcripts.
Petra Vaux +7 more
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SynopsisPre-messenger RNA (pre-mRNA) splicing or the removal of introns from pre-mRNA transcripts is a key process in the maturation of mRNA. This process requires the assembly of a large complex of RNA and protein molecules, called the splicosome, on the pre-mRNA transcripts.
Petra Vaux +7 more
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Pre-mRNA splicing in the new millennium
Current Opinion in Cell Biology, 2001The past year has witnessed refinements in models of spliceosome assembly pathways and in the understanding of how splicing factors of the serine/arginine-rich (SR) protein family function. The role of splicing in human genetic diseases has also received a lot of attention recently as exonic splicing enhancers become better understood.
Michelle L. Hastings, Adrian R. Krainer
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Structural basis of pre-mRNA splicing
Science, 2015Structure and function of the spliceosome When RNA is transcribed from DNA in the eukaryotic cell nucleus, the initial transcript includes noncoding introns that must be spliced out. This splicing is done by a complex macromolecular machine, the spliceosome, which comprises five small nuclear RNAs and more than 100 associated ...
J. Hang +3 more
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1994
This chapter is focused on the splicing of nuclear pre-mRNAs in higher plants. Other aspects of plant mRNA processing such as polyadenylation and mRNA stability are discussed in recent reviews.1, 2 Nothing is known about the localization of pre-mRNA processing events in the plant nucleus or mRNA transport to the cytoplasm.
Ueli Klahre +3 more
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This chapter is focused on the splicing of nuclear pre-mRNAs in higher plants. Other aspects of plant mRNA processing such as polyadenylation and mRNA stability are discussed in recent reviews.1, 2 Nothing is known about the localization of pre-mRNA processing events in the plant nucleus or mRNA transport to the cytoplasm.
Ueli Klahre +3 more
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2017
The splicing of precursor messenger RNA (pre-mRNA) requires the precise cleavage and formation of multiple phosphodiester bonds in nascent pre-mRNA polymers in order to produce a protein coding message that can be properly translated by the ribosome. Despite the precision of this process, the spliceosome maintains considerable flexibility to include ...
Gary Mitchell Karp +2 more
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The splicing of precursor messenger RNA (pre-mRNA) requires the precise cleavage and formation of multiple phosphodiester bonds in nascent pre-mRNA polymers in order to produce a protein coding message that can be properly translated by the ribosome. Despite the precision of this process, the spliceosome maintains considerable flexibility to include ...
Gary Mitchell Karp +2 more
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2016
The splicing of pre-mRNA was discovered in the late 1970s. It soon became apparent that pre-mRNA can be alternatively spliced, providing eukaryotes with an important additional mechanism with which to regulate gene expression. Alternative splicing is prevalent and often highly complex.
Sebastian Oltean, Michael Ladomery
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The splicing of pre-mRNA was discovered in the late 1970s. It soon became apparent that pre-mRNA can be alternatively spliced, providing eukaryotes with an important additional mechanism with which to regulate gene expression. Alternative splicing is prevalent and often highly complex.
Sebastian Oltean, Michael Ladomery
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