Results 351 to 360 of about 270,676 (398)
Some of the next articles are maybe not open access.
Pre-mRNA splicing in higher plants
Trends in Plant Science, 2000Most plant mRNAs are synthesized as precursors containing one or more intervening sequences (introns) that are removed during the process of splicing. The basic mechanism of spliceosome assembly and intron excision is similar in all eukaryotes. However, the recognition of introns in plants has some unique features, which distinguishes it from the ...
Dominika A. Wieczorek Kirk +3 more
openaire +3 more sources
Alterations of pre‐mRNA splicing in cancer
Genes, Chromosomes and Cancer, 2005AbstractRecent genomewide analyses of alternative splicing (AS) indicate that up to 70% of human genes may have alternative splice forms, suggesting that AS together with various posttranslational modifications plays a major role in the production of proteome complexity.
Aija Linē +3 more
openaire +3 more sources
Nuclear pre‐mRNA splicing in yeast
Yeast, 1989In this review I will summarize the genetic and biochemical approaches that have been used in Saccharomyces cerevisiae to determine the pathway of nuclear pre-mRNA splicing and to identify both cis- and trans-acting elements in these ...
openaire +2 more sources
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects
Nature reviews genetics, 2022M. Rogalska +2 more
semanticscholar +1 more source
Regulation of Alternative Pre-mRNA Splicing
2014Alternative splicing plays a prevalent role in generating functionally diversified proteomes from genomes with a more limited repertoire of protein-coding genes. Alternative splicing is frequently regulated with cell type or developmental specificity and in response to signaling pathways, and its mis-regulation can lead to disease.
Miguel Coelho, Christopher W.J. Smith
openaire +3 more sources
Protein functions in pre-mRNA splicing
Current Opinion in Cell Biology, 1997Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that potentially act as novel RNA helicases, GTPases, or protein isomerases. Novel protein-protein and protein-RNA interactions that are required for functional spliceosome formation have ...
Cindy L. Will, Reinhard Lührmann
openaire +2 more sources
Trans splicing of nuclear pre-mRNAs
Cell, 1990Chez les Nematodes et Trypanosomes, les substrats et facteurs, qui participent a l'epissage trans, des pre-mRNA sont etudies. Les differences qui existent entre ces modeles permettent d'avoir un apercu de l'evolution de la maturation des RNAs des protozoaires aux ...
openaire +3 more sources
Pre-mRNA splicing aberrations and cancer
Frontiers in Bioscience, 2008Splicing requires the accurate recognition of exonic sequences from the surrounding thousands of nucleotides of intronic sequence and is achieved by the coordinate interplay of splicing regulatory elements in genes and the trans-acting RNA and protein molecules to which they bind.
Pettigrew, C.A., Brown, M.A.
openaire +4 more sources
Regulation of mammalian pre-mRNA splicing
Science in China Series C: Life Sciences, 2009In eukaryotes, most protein-coding genes contain introns which are removed by precursor messenger RNA (pre-mRNA) splicing. Alternative splicing is a process by which multiple messenger RNAs (mRNAs) are generated from a single pre-mRNA, resulting in functionally distinct proteins.
openaire +3 more sources
Biochemistry and regulation of pre-mRNA splicing
Current Opinion in Cell Biology, 1996During the past year, significant advances have been made in the field of pre-mRNA splicing. It is now clear that members of the serine-arginine-rich protein family are key players in exon definition and function at multiple steps in the spliceosome cycle.
Donald C. Rio +2 more
openaire +3 more sources