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SPLICE SITE SELECTION IN PLANT PRE-mRNA SPLICING
Annual Review of Plant Physiology and Plant Molecular Biology, 1998▪ Abstract The purpose of this review is to highlight the unique and common features of splice site selection in plants compared with the better understood yeast and vertebrate systems. A key question in plant splicing is the role of AU sequences and how and at what stage they are involved in spliceosome assembly.
C. G. Simpson, John W. S. Brown
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snRNAs as the catalysts of pre-mRNA splicing
Current Opinion in Chemical Biology, 2005The spliceosome, the gigantic molecular machine that performs pre-mRNA splicing in eukaryotes, contains over 200 different proteins and five RNA molecules. The central role played by the spliceosomal RNAs in splicing has led to the hypothesis that, like the ribosome, the spliceosome is an RNA-centric enzyme and a relic from the RNA world.
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The Biochemistry of PRE-mRNA Splicing
1995The primary transcripts of most nuclear protein-coding genes of eu-karyotes are interrupted by intervening sequences (or introns) that are removed from the pre-mRNA in a process termed splicing. The coding sequences (or exons) are joined to form the mature mRNA that is subsequently exported to the cytoplasm.
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Mechanisms of fidelity in pre-mRNA splicing
Current Opinion in Cell Biology, 2000The pre-mRNA splicing machinery consists of five small nuclear RNAs (U1, U2, U4, U5 and U6) and more than fifty proteins. Over the past year, important advances have been made in understanding how these factors function to achieve fidelity in splicing.
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Human pre-mRNA splicing signals
Journal of Theoretical Biology, 1991A sample of 764 pairs of human pre-mRNA exon-intron and intron-exon boundaries, extracted from the European Molecular Biology Laboratory data bank, is analyzed to provide a species-optimized characterization of donor and acceptor sites, evaluate the information content of the two signals (found to be about 8 and 9 bits respectively) and check the ...
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Genome-Wide Survey of Human Alternative Pre-mRNA Splicing with Exon Junction Microarrays
Science, 2003Jason M. Johnson +9 more
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m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination
Nature, 2016Irmgard U. Haussmann +6 more
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MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis
Nature, 2015Cheryl M. Koh +12 more
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Alternative pre-mRNA splicing and proteome expansion in metazoans
Nature, 2002T. Maniatis, Bosiljka Tasic
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