Results 51 to 60 of about 13,025,887 (300)

Influences on pupils' self-perceptions in primary school: enjoyment of school,anxiety and isolation, and self-image in year 5 [PDF]

, 2008
This report presents the results of analyses of pupils’ self-perceptions in primary school. It is part of the longitudinal Effective Pre-school and Primary Education 3-11 (EPPE 3-11) research project funded by the Department for Children, Schools and
Smees, R., Siraj-Blatchford, I., Sammons, P., Taggart, B., Melhuish, Edward C., Sylva, K.   +5 more
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Identification of ferroptosis related genes and pathways in prostate cancer cells under erastin exposure

BMC Urology
Background Few studies are focusing on the mechanism of erastin acts on prostate cancer (PCa) cells, and essential ferroptosis-related genes (FRGs) that can be PCa therapeutic targets are rarely known.
Fan Wu, Fei Huang, Nili Jiang, Jinfeng Su, Siyi Yao, Boying Liang, Wen Li, Tengyue Yan, Sufang Zhou, Qingniao Zhou   +9 more
doaj   +1 more source

SMP30 Interacts with ROCK1 to Inhibit HCC Invasiveness by Effecting the Epithelial-Mesenchymal Transition

Frontiers in Bioscience-Landmark
Background: The senescence marker protein 30 (SMP30) is a calcium-binding protein whose expression decreases with age, and is closely associated with hepatocellular carcinoma (HCC) development.
Shunxin Zheng, Zhijing Mo, Zhilue Lv, Yuan Zhuang, Sufang Zhou   +4 more
doaj   +1 more source

Promoting children’s wellbeing in an educational context

Problemy Wczesnej Edukacji, 2016
The topicality and the context of this research are related to the phenomenon of wellbeing and factors influencing it, regarding early childhood and primary school. The aim is to study, analyse, and identify the key factors of promoting the wellbeing and
Linda Grīga
doaj   +1 more source

Effective pre-school, primary and secondary education project (EPPSE 3-14): influences on students' development in Key Stage 3: social-behavioural outcomes in Year 9 [PDF]

, 2011
The Effective Pre-school, Primary and Secondary Education Project (EPPSE) has investigated the academic and social-behavioural development of approximately 3,000 children from the age of 3+ years since 1997.
Draghici, D., Smees, R., Smees, R, Siraj-Blatchford, Iram, Toth, Katalin, Taggart, Brenda, Taggart, B., Sylva, K., Melhuish, E, Sammons, Pam, Sammons, P., Siraj-Blatchford, I, Sammons, Pamela, Draghici, Diana, Sammons, P, Draghici, D, Smees, Rebecca, Sylva, K, Sylva, Kathy, Toth, K, Siraj-Blatchford, I., Melhuish, Edward C., Melhuish, Edward, Taggart, B   +23 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Prevalencia de protozoos intestinales en 79 niños de 2 a 5 años de edad de un hogar infantil estatal en Circasia, Quindío Prevalence of intestinal Protozoa in79 Children 2 to 5 years old from a state nursery in Circasia, Quindío

Infectio, 2010
Introducción: Los parásitos intestinales se consideran un problema de salud pública en los países en desarrollo y afecta a individuos de todas las edades y sexos, pero se presentan, sobre todo, en los primeros años de vida.
Jonathan Andrés Arias, Gloria Elcy Guzmán, Fabiana María Lora-Suárez, Elizabeth Torres, Jorge Enrique Gómez   +4 more
doaj