Results 111 to 120 of about 1,386,765 (307)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Logical bases of pre-trial investigation planning

Uzhhorod National University Herald. Series: Law
The article reflects on the nature of pre-trial investigation planning, taking into account established views on the forensic version as the only logical basis for this process. The author notes that within the framework of modern criminalistics theory, the forensic version is almost unanimously regarded as the logical basis for investigation planning.
I. Kubariev, S. Barhan
openaire   +3 more sources

Деякі аспекти забезпечення прав учасників кримінального провадження під час ознайомлення з матеріалами досудового розслідування [PDF]

, 2015
Паршак, С. А. Деякі аспекти забезпечення прав учасників кримінального провадження під час ознайомлення з матеріалами досудового розслідування / Паршак Сергій Анатолійович // Наше право. - 2015. - № 4. - С. 126-130.Паршак С. А. "Деякі аспекти забезпечення
Parshak, S. A., Паршак, С. А.
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Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Protecting the Rights of War Crimes Victims: Determining Ways to Prevent Their Secondary Victimization

Архів кримінології та судових наук
The modern conditions of our state’s development, including the geopolitical situation and the state of the security environment, highlight the need to enhance the efficiency of law enforcement agencies, ensure effective resistance to war crimes and ...
Hanna Spitsyna, Ivan Iemets
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

International Cooperation in EU Pre-Trial Investigations and Its Future Role in Ukraine’s Legal Reform

Journal of Law and Legal Reform
This article examines international cooperation between law enforcement agencies within the European Union (EU) during pre-trial investigations, guided by the Association Agreement between Ukraine and the EU.
Oleksandr I. Kozachenko, Volodymyr Zarosylo, Mykola O. Gelemei, Mykhailo I. Stankovych, Mykola M. Yatsun   +4 more
doaj   +1 more source

Форми закінчення досудового розслідування за Кримінальним процесуальним кодексом України 2012 р [PDF]

, 2015
Торбас О. О. Форми закінчення досудового розслідування за Кримінальним процесуальним кодексом України 2012 р : автореф. дис. ... канд. юрид. наук : 12.00.09 / О. О. Торбас; кер. роботи Ю. П. Аленін; Нац.
Torbas, Olexandr O., Торбас, Александр Александрович, Торбас, Олександр Олександрович   +2 more
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