Results 121 to 130 of about 391,018 (258)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The impact of (poly)phenol-rich sugarcane extract intervention on markers of gastrointestinal integrity and systemic inflammation in response to exertional-heat stress. [PDF]

J Int Soc Sports Nutr
Hewawansa UHAJ, Henningsen K, Vilela Silva Daniel N, In S, Sugay G, Houghton MJ, Barber E, Williamson G, Costa RJS.   +8 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

A visual framework for classifying adaptive design clinical trials using the GATE frame and PICO terminology. [PDF]

Dialogues Health
Lora D, Lalueza Blanco A, Maestro de la Calle G, García Reyne A, Ruíz-Ruigómez M, Calderón EJ, Menéndez-Orenga M.   +6 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Design and rationale of the WE-CARE-HF-CMR trial: Cardiorenal care on wheels for asymptomatic heart failure patients (NCT07185100). [PDF]

J Cardiovasc Magn Reson
Li JJ, Thiede G, Götze C, Exarchos V, Meuwly C, Werhahn SM, Beyer RE, Müller ML, Bigvava T, Stehning C, Remppis BA, Wieditz J, Sack S, Heer T, Sroka M, Nagel E, Hays AG, Duvigneau G, Blankenberg S, Steen H, Frey N, Baldus S, Seuthe K, Lorbach R, Rödicker F, Scharf S, Hilgendorf I, Landmesser U, Friede T, Falk V, Doeblin P, Kelle S.   +31 more
europepmc   +1 more source

TAX EVASION: INITIATION OF PRE-TRIAL INVESTIGATION, PRIORITY ACTIONS, FOCUS AREAS OF THE PRE-TRIAL INVESTIGATION BODY

Law Bulletin, 2023
openaire   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Jet ventilation and hemodynamic stability during pulmonary vein isolation: ventilatory and hemodynamic outcomes from a randomized controlled trial (Secondary analysis under EEG-Guided Total Intravenous Anesthesia). [PDF]

BMC Anesthesiol
Maseri A, Bairy L, Bihin B, Dormal F, Collet B, Hardy M, Delhez Q, Dubois P, Xhaët O, Robaye B.   +9 more
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source