Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Detention as a violation of the fundamental right to protection
Науково-інформаційний вісник Івано-Франківського університету права імені Короля Данила ГалицькогоPurpose. The purpose of the work is to study the current legislation that violates a person’s fundamental right to protection when the preventive measure of detention is chosen for him. Method.
Lototskyi M., Dzundza L.
doaj +1 more source
Dose rationale and pharmacokinetics of dexmedetomidine in mechanically ventilated new-borns : impact of design optimisation [PDF]
, 2019 Purpose: There is a need for alternative analgosedatives such as dexmedetomidine in neonates. Given the ethical and practical difficulties, protocol design for clinical trials in neonates should be carefully considered before implementation.
Allegaert, Karel +8 more
core +5 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Особливості адміністративно-правового статусу слідчих підрозділів органів внутрішніх справ [PDF]
, 2014 Петрухін, К. Є. Особливості адміністративно-правового статусу слідчих підрозділів органів внутрішніх справ [Електронний ресурс] / К. Є. Петрухін // Форум права. – 2014. – № 1. – С. 412–417 .
Petrukhin, K. E. +1 more
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European Court of Human Rights : Beizaras and Levickas v. Lithuania [PDF]
, 2020 In a case about hate speech against homosexuals on Facebook, the European Court of Human Rights (ECtHR) delivered an important and well-documented judgment (of 61 pages.) The ECtHR found that the Lithuanian authorities have violated the European ...
Voorhoof, Dirk
core
Developing a complex intervention to improve prescribing safety in primary care:mixed methods feasibility and optimisation pilot study [PDF]
, 2014 Objectives (A) To measure the extent to which different candidate outcome measures identified high-risk prescribing that is potentially changeable by the data-driven quality improvement in primary care (DQIP) intervention.(B) To explore the value of ...
Dreischulte, Tobias +2 more
core +7 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Функции квесторов архаического Рима в уголовном судопроизводстве [PDF]
, 2009 Вопрос о функциях римских квесторов в сфере уголовного судопроизводства нуждается в специальном исследовании по нескольким причинам: во-первых, для изучения ранних форм уголовного процесса в Риме, во-вторых, для исследования проблемы происхождения ...
Dement'eva, Vera Viktorovna +1 more
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