Results 141 to 150 of about 2,341,004 (362)

DEFENDER’S ACTIVITY AS AN IMPORTANT GUARANTEE OF ENSURING THE RIGHT TO DEFENSE DURING THE GRANTING OF PERMISSION TO CONDUCT A SPECIAL PRE-TRIAL INVESTIGATION

, 2021
Ye. Pelikhos
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Ensuring the security of assistance to the investigation as an independent condition for the conclusion of a pre-trial cooperation agreement with the suspect, accused

, 2022
Veronika V. Kolesnik
openalex   +1 more source

Методичні рекомендації щодо особливостей досудового розслідування стосовно окремої категорії осіб [PDF]

, 2013
Методичні рекомендації щодо особливостей досудового розслідування стосовно окремої категорії осіб / Юхно О.О., Бондаренко О.О., Глобенко Г.І. та ін. // Актуальні питання діяльності слідчих підрозділів органів внутрішніх справ України : зб. наук. пр. ф-ту
Bondarenko, O. O., Chycha, R. P., Danylenko, A. V., Globenko, G. I., Kochura, O. O., ORCID: http://orcid.org/0000-0001-6077-4591, ORCID: http://orcid.org/0000-0001-6901-7298, ORCID: http://orcid.org/0000-0002-1452-5815, ORCID: http://orcid.org/0000-0002-1533-9213, ORCID: http://orcid.org/0000-0002-4771-0531, ORCID: http://orcid.org/0000-0002-7721-2955, ORCID: http://orcid.org/0000-0003-3267-2840, ORCID: http://orcid.org/0000-0003-0638-2911, Romaniuk, V. V., Sychov, S. O., Yukhno, O. O., Бондаренко, О. О., Глобенко, Г. І., Даниленко, А. В., Кочура, О. О., Романюк, В. В., Сичов, С. О., Чича, Р. П., Юхно, О. О.   +23 more
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Unified register of pre-trial investigations as part of the information and communication system of pre-trial investigation

Analytical and Comparative Jurisprudence
It is indicated that the digitalization of public administration is a key priority for the development of a modern state. Electronic document flow accelerates information exchange, simplifies data processing and reduces budget costs. The digital transformation of criminal justice bodies ensures effective control, compliance with the rule of law and ...
openaire   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

PECULIARITIES OF INVESTIGATOR'S IMPLEMENTATION OF IMMEDIACY PRINCIPLE DURING THE EXAMINATION OF TESTIMONY, ITEMS AND DOCUMENTS IN PRE-TRIAL INVESTIGATION

, 2023
V.V. Hvozdiuk, N.S. Morhun, V. V. Siedakova   +2 more
openalex   +1 more source

European Court of Human Rights : Beizaras and Levickas v. Lithuania [PDF]

, 2020
In a case about hate speech against homosexuals on Facebook, the European Court of Human Rights (ECtHR) delivered an important and well-documented judgment (of 61 pages.) The ECtHR found that the Lithuanian authorities have violated the European ...
Voorhoof, Dirk
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source