Results 101 to 110 of about 96,102 (259)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Judicial responses to pre-trial procedural violations in international criminal proceedings [PDF]

, 2016
This book provides an in-depth examination of the judicial response at the international criminal tribunals – the UN ad hoc Tribunals and the International Criminal Court – to the violation of procedural standards in the pre-trial phase of the ...
Pitcher, K.M.
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Interaction of an investigator with a specialist during the pre-trial proceedings

Статтю присвячено дослідженню проблемних аспектів взаємодії слідчого зі спеціалістом на досудовому провадженні. Проаналізовано норми кримінального процесуального законодавства України з урахуванням останніх змін, пов’язаних з оптимізацією діяльності ...
Бойко, Олексій, Boiko, Oleksii   +1 more
core   +1 more source

Indictment and amending it during the pre-trial proceedings

, 2023
Bakalaura darbs ir par apsūdzību un tās grozīšanu kriminālprocesā, koncentrējoties tieši uz pirmstiesas procesu. Bakalaura darbā tiek apkopota informācija par apsūdzības kā lēmuma problemātiku, galvenokārt izmantojot tiesu prakses un tiesību zinātnieku
Bergmanis, Mariuss Raits
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

The essence of specialized knowledge used in the investigation of criminal offenses against justice

Архів кримінології та судових наук
Given the importance of special knowledge in solving tactical tasks of investigation and tasks of criminal proceedings, the purpose of the article is to define the concept, essence and typical forms of special knowledge used in the investigation of ...
Volodymyr Grytsenko
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Selected victim protection measures in ordinary criminal proceedings

Journal of Modern Science
The victim becomes a participant in the criminal proceedings not because he or she has consciously made such a decision. It is almost always that the victim becomes a participant against their will, which is caused by a direct violation or threat to its ...
Ewa Kruk
doaj   +1 more source