Results 81 to 90 of about 96,102 (259)
The public prosecutor in a pre-trial proceedings
, 2018 The public prosecutor in a pre-trial criminal proceedings Abstract The Diploma thesis is concerned with the role of a Public Prosecutor in pre-trial criminal proceedings.
Hájek, Jaroslav
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
PECULIARITIES OF INTERROGATING JUVENILE VICTIM IN PRE-TRIAL PROCEEDINGS
, 2023 The aim of the research is to study, analyse and discover issues of peculiarities of interrogating a juvenile, who has suffered from a criminal offense against morality and sexual integrity, in the pre-trial proceedings. The paper deals with study of the
Božko-Čače, Margarita
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2014 Autores izvēlētais maģistra darba temats ir „Izmeklēšanas darbības pirmstiesas kriminālprocesā un izmeklēšanas tiesneša loma to īstenošanā.” Pēc autores domām šis pētījums ir aktuāls ar to, ka izmeklēšanas darbības vienmēr ir bijušas kā galvenais ...
Koleda, Anna
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Victim in pre-trial criminal proceedings
, 2013 Bakalaura darba tēma ir „Cietušais pirmstiesas kriminālprocesā”. Autore uzskata, ka cietušais kā pirmstiesas kriminālprocesa dalībnieks ieņem vienu no būtiskākajām vietām kriminālprocesā, jo parasti cietušais ir viens no galvenajiem informātoriem un ...
Švaikovska, Jeļena
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