Results 71 to 80 of about 9,640,698 (298)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
, 2015 The length of proceedings before the ICC has been an issue of concern. ICC proceedings at pre-trial and trial have been slow and can be improved. Based on a study of existing cases (e.g.
Friman Håkan
core +1 more source
Проблеми Законності, 2019 It is indicated a new participant in criminal proceedings in Part 1 of Art. 3, paragraph 161 the CPC of Ukraine – another person whose rights or legitimate interests are limited during the pre-trial investigation (hereinafter – another person).
Tatyana Korcheva
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
On the implementation of the law enforcement function of the state in criminal procedure
Jus StrictumThe paper presents the author’s vision of the organization of balanced pre-trial proceedings based on the functional delineation of the activities of state authorities ensuring the fulfillment of public-law duties of the state in criminal procedure ...
Svetlana I. Vershinina
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
LIMITS OF COMPETENCE OF AN INVESTIGATING JUDGE IN THE PRE-TRIAL CRIMINAL PROCEEDINGS [PDF]
, 2019 The Institute of Investigation Judge exists in a number of European countries; the Institute of Investigation Judge was introduced in Latvia in 2005. Historically, the investigating judge was created to investigate, but today the institute has survived ...
Trukšāne, Zane
core +1 more source
Bulletin of Kharkiv National University of Internal AffairsIt is emphasised that the system of international legal standards for ensuring human rights and freedoms at the pre-trial investigation stage is fundamental to any democratic state governed by the rule of law.
S. M. Danylo
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source