Results 91 to 100 of about 96,102 (259)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Grounds and conditions for the application of preventive measures during the pre-trial investigation of corruption criminal offenses

Law and Safety
The article is devoted to clarifying the content of the grounds and conditions for the application of preventive measures during the pre-trial investigation of corruption criminal offenses.
V. V. Romaniuk, R. I. Login
doaj   +1 more source

Prosecutor´s role in the pre-trial proceedings

, 2013
V této práci se primárně věnuji charakterizaci a systematizaci jednotlivých oprávnění a povinností státního zástupce v přípravném řízení. V úvodních kapitolách práce se zabývám obecným úvodem do problematiky.
Gorská, Veronika
core  

LIMITS OF COMPETENCE OF AN INVESTIGATING JUDGE IN THE PRE-TRIAL CRIMINAL PROCEEDINGS

, 2019
The Institute of Investigation Judge exists in a number of European countries; the Institute of Investigation Judge was introduced in Latvia in 2005. Historically, the investigating judge was created to investigate, but today the institute has survived ...
Trukšāne, Zane
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Fast-track pre-trial proceedings

, 2015
This thesis deals with the institute of summary preliminary proceedings in the context of past and current legislation and also the reasons that led to its introduction into law.
Trojanová, Monika
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Closing the Injustice Gap: Reconstructing Pre-trial Proceedings as an Effective Remedy for Victims of Terminated Preliminary Inquiries

Jurnal Konstitusi
This article analyses the constitutional and procedural implications of the absence of pre-trial authority to review decisions to terminate preliminary inquiries (penghentian penyelidikan) in Indonesia’s criminal justice system.
Adam Ilyas, Fachrizal Afandi, Indah Dwi Qurbani   +2 more
doaj   +1 more source

Judge in pre-trial proceedings [PDF]

Postavení soudce v přípravném řízení Tato rigorózní práce se zabývá postavením soudce v přípravném řízení. Práce shrnuje aktuálně platnou a účinnou právní úpravu týkající se postavení soudce v přípravném řízení a zároveň obsahuje praktické poznatky o ...
Hložánek, Petr
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