Results 91 to 100 of about 751,049 (343)

Zákonná příslušnost státního zastupitelství jako právní hodnota [PDF]

open access: yes, 2013
Článek se zabývá na konkrétních kauzách otázkou příslušnosti státního zastupitelství v trestním řízení. Příslušnost státního zastupitelství není stanovena ústavou, ale jen zákony. I ty jsou však závazné.
Koudelka Zdeněk
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

APPLICATION OF A PRELIMINARY (PRE-TRIAL) CRIMINAL PROCEEDINGS MODELING METHOD

open access: yesHumanities & Social Sciences Reviews, 2019
Purpose: The article conducts the study application of a preliminary (pre-trial) criminal proceedings modeling method. Methodology: We have shown the important role of blended learning in the maintenance and development of the subject-subject model of interaction between students and teachers.
Khairullina R.   +3 more
openaire   +2 more sources

Деякі аспекти забезпечення прав учасників кримінального провадження під час ознайомлення з матеріалами досудового розслідування [PDF]

open access: yes, 2015
Паршак, С. А. Деякі аспекти забезпечення прав учасників кримінального провадження під час ознайомлення з матеріалами досудового розслідування / Паршак Сергій Анатолійович // Наше право. - 2015. - № 4. - С. 126-130.Паршак С. А. "Деякі аспекти забезпечення
Parshak, S. A., Паршак, С. А.
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Reform and Digitalization of Pre-trial Proceedings in Criminal Proceedings of the Kyrgyz Republic

open access: yesBulletin of Science and Practice, 2020
The article is devoted to the peculiarities of changes in the model of criminal proceedings in the Kyrgyz Republic and the definition of ‘criminal proceedings’ is given in a new edition. It has been established that pre-trial proceedings as a stage in the criminal process; begins with the registration of statements and messages and is the initial ...
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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