Results 91 to 100 of about 2,759 (195)

Interpretation of Chemistry, Hematology and Coagulation Laboratory Results in Early‐Phase Clinical Pharmacology Trials; a Retrospective Analysis Based on the Placebo Arm of Randomized‐Controlled Trials

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Early‐phase clinical trials focus heavily on demonstrating safety and tolerability of drug candidates. Clinical laboratory test results outside of reference intervals (RIs) are often interpreted as possible indicators of harm. However, values outside RIs do not necessarily constitute drug‐induced adverse effects.
Jannik Rousel, Tessa Niemeyer‐van der Kolk, Matthijs Moerland, Robert Rissmann, Naomi B. Klarenbeek, Maurits F. J. M. Vissers, Jacobus Burggraaf   +6 more
wiley   +1 more source

Preanalytical requirements of urinalysis

, 2014
Urine may be a waste product, but it contains an enormous amount of information. Well-standardized procedures for collection, transport, sample preparation and analysis should become the basis of an effective diagnostic strategy for urinalysis.
Joris Delanghe, Delanghe, Joris, Speeckaert, Marijn, Marijn Speeckaert   +3 more
core   +1 more source

Assessing the exercise‐related kinetics of circulating cell‐free DNA, circulating tumour DNA, DNase I activity and cytokines in patients with solid tumours: A pilot study

Experimental Physiology, Volume 111, Issue 6, Page 2963-2974, 1 June 2026.
Abstract Circulating cell‐free DNA (cfDNA), circulating tumour DNA (ctDNA) and inflammatory cytokines have prognostic and predictive value in oncology. However, the effects of acute exercise on cfDNA levels are unknown. Here, we explore the kinetics of cfDNA, ctDNA and cytokines upon an incremental exercise test in a pilot cohort of cancer patients ...
Elmo W. I. Neuberger, Alexandra Brahmer, Tobias Ehlert, Suzan Botzenhardt, Alfonso De Falco, Birgit Enders, Patricia S. Hähnel, Achim Heintz, Carl C. Schimanski, Thomas Kindler, Perikles Simon   +10 more
wiley   +1 more source

Assessment and Quantification of Preanalytical errors - A Laboratory based study from a Tertiary Care Institution

Background: Pre analytical errors are the main cause of laboratory dysfunctions which compromise the reliability of diagnostic results. These errors occur during the phase before actual sample analysis.
K, Reshma, Pandya, Darshna, Agnihotram, Gopinath   +2 more
core   +1 more source

Evaluation of Pre-Analytical Errors in Clinical Biochemistry Laboratory of a Tertiary Care Center in India

Journal of Clinical and Basic Research, 2021
Background and objectives: Laboratory medicine is equally challenged by economic and new technological pressures. Clinical laboratories have undergone major change due to advancement of technology, which has improved the decision making of clinicians but
KAPILA GAIKWAD, SOHAN SELKAR
doaj  

What Is Your Diagnosis? Abnormal WDF Scattergram From the Sysmex XN‐1000V in a Cat

Veterinary Clinical Pathology, EarlyView.
Javier Martínez‐Caro, Laura Chaves‐Falcón, Marta Lemos, Xavier Roura, Luis Bosch, Josep Pastor   +5 more
wiley   +1 more source

The Contribution of Education to the Correction of Preanalytical Errors in Laboratory Testing: A Systematic Review

Introduction: laboratory medicine generates clinical information by analyzing various analytes in body fluids. This process requires trained personnel capable of developing strategies to prevent errors that could compromise patient safety. Recent studies
Azocar González, Claudia, Azocar González , Ignacio, Sepúlveda Maturana, Francisca, Ramírez-Pereira , Mirliana, González González , María Loreto   +4 more
core   +1 more source

Preanalytical quality improvement : in quality we trust

, 2013
Total quality in laboratory medicine should be defined as the guarantee that each activity throughout the total testing process is correctly performed, providing valuable medical decision-making and effective patient care.
Bowen, Raffick A, Behulova, Darina, Church, Stephen, Palicka V, Palicka, Vladimir, Simundic AM, Kitchen, Steve, Behúlová D, Plebani M, Lippi, Giuseppe, Grankvist, Kjell,, Nybo, Mads, Nybo M, Becan-McBride, Kathleen, Grankvist K, Becan McBride K, Nauck M, Nikolac, Nora, Sandberg, Sverre, Delanghe, Joris, Sandberg S, Kitchen S, Nikolac N, Simundic A.M., Simundic, Ana-Maria, Church S, Plebani, Mario, Bowen RA, Lippi G, Delanghe J, Grankvist, Kjell, Nauck, Matthias, Bowen, Raffick A.   +32 more
core   +1 more source

Preanalytical errors in pediatric blood sampling: a systematic review of common challenges and risks

Türk Biyokimya Dergisi
This systematic review aims to identify common preanalytical errors in pediatric blood sampling.
Şenol Şule
doaj   +1 more source

Preanalytical Variables Affecting the Integrity of Human Biospecimens in Biobanking

, 2015
BACKGROUND: Most errors in a clinical chemistry laboratory are due to preanalytical errors. Preanalytical variability of biospecimens can have significant effects on downstream analyses, and controlling such variables is therefore fundamental for the ...
Vaught, Jim, Ellervik, Christina
core   +1 more source