Results 61 to 70 of about 2,248 (168)

Assessing the exercise‐related kinetics of circulating cell‐free DNA, circulating tumour DNA, DNase I activity and cytokines in patients with solid tumours: A pilot study

Experimental Physiology, EarlyView.
Abstract Circulating cell‐free DNA (cfDNA), circulating tumour DNA (ctDNA) and inflammatory cytokines have prognostic and predictive value in oncology. However, the effects of acute exercise on cfDNA levels are unknown. Here, we explore the kinetics of cfDNA, ctDNA and cytokines upon an incremental exercise test in a pilot cohort of cancer patients ...
Elmo W. I. Neuberger, Alexandra Brahmer, Tobias Ehlert, Suzan Botzenhardt, Alfonso De Falco, Birgit Enders, Patricia S. Hähnel, Achim Heintz, Carl C. Schimanski, Thomas Kindler, Perikles Simon   +10 more
wiley   +1 more source

Post‐surgery level of circulating DNA in stage III colon cancer patients: Impact on the reliability of minimal residual disease detection

International Journal of Cancer, Volume 158, Issue 10, Page 2771-2783, 15 May 2026.
What's New? Circulating nuclear DNA (cir‐nDNA)‐based assessment of minimal residual disease (MRD) offers powerful post‐surgery prognostic insight for stage III colon cancer (CC). Sparse knowledge of post‐surgical variations and origins in cir‐nDNA, however, has limited its clinical application.
Andrei Kudriavtsev, Saidi Daoud, Catalina Isabel Cofre Muñoz, Alexia Mirandola, Ekaterina Pisareva, Javier Gonzalo Ruiz, Marco Macagno, Nadia Saoudi Gonzalez, Evelyne Crapez, Marc Ychou, Ramon Salazar Soler, Elisabetta Fenocchio, Paula X. Fernandez Calotti, Thibault Mazard, Cristina Santos Vivas, Elena Elez, Federica Di Nicolantonio, Alain R. Thierry   +17 more
wiley   +1 more source

Impact of intervention on preanalytical errors assessed by six sigma and Pareto’s principle [PDF]

Al Ameen Journal of Medical Sciences
Introduction: Preanalytical steps are the major sources of error in the clinical laboratory. The analytical errors can be corrected by quality control procedures but there is a need for stringent quality checks in the preanalytical area as these ...
Sweta Kulkarni, S. Vinothini, Wilma Delphine Silvia CR   +2 more
doaj  

Study of pre-analytical errors in haematology laboratory: A single-centre experience

Journal of Medical Evidence, 2020
Aims and Objectives: Total quality management is an essential component of laboratory to maintain quality and includes pre-analytical, analytical and post-analytical phases. Pre-analytical phase starts from ordering investigation by the clinician till it
Harish Chandra, Arvind Kumar Gupta, Neha Singh   +2 more
doaj   +1 more source

Spatial transcriptomics in epilepsy research: Early successes, opportunities, and challenges

Epilepsia, EarlyView.
Donald J. Phillips, Autumn S. Ivy, Samuel Guzman, Saman Hazany, Xiangmin Xu   +4 more
wiley   +1 more source

Making Molecular Diagnostics Faster

International Journal of Laboratory Hematology, Volume 48, Issue 2, Page 272-280, April 2026.
ABSTRACT Background Over the past 40 years, molecular diagnostic methods have evolved from multi‐step, time‐consuming protocols towards either rapid targeted tests or expansive, massively parallel testing. Aims Here we consider the speed limits of targeted molecular diagnostics, considering the three sequential required steps: nucleic acid preparation,
Carl T. Wittwer, Luming Zhou, Felix Ye, Adam Millington, Adrian de Cola, Noriko Kusukawa   +5 more
wiley   +1 more source

Pre-analytical Errors at the Chemical Pathology Laboratory of a Teaching Hospital [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: The Chemical Pathology Laboratory at the University Hospital of the West Indies (UHWI) processes specimens received from inpatients, the outpatient department and other medical facilities in Jamaica. Specific rejection criteria are used
Marlene A Tapper, James C Pethick, Lowell L Dilworth, Donovan A Mc Growder   +3 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, Volume 20, Issue 3, Page 588-610, March 2026.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Pre-Analytical Errors in Blood Homocysteine Assays [PDF]

Al Ameen Journal of Medical Sciences, 2009
Blood homocysteine is a major biomarker for cardiovascular as well as other disorders. Several published studies reported inconsistent homocysteine levels with variable ranges.
A. S. Yadav, Vinod R. Bhagwat
doaj  

Clinical Application of Peripheral Blood Biomarkers for Solid Tumors

MedComm, Volume 7, Issue 3, March 2026.
Peripheral blood biomarkers provide a minimally invasive, dynamic, and potentially more accurate means to obtain a comprehensive tumor profile. Technologies for detecting them are advancing, and with the help of artificial intelligence, they are being used more and more often for cancer diagnosis, prognostic assessment, and therapeutic monitoring ...
Xinru Tu, Mengyan Tu, Junfen Xu
wiley   +1 more source