Results 51 to 60 of about 8,556 (220)

Androgen-induced exosomal miR-379-5p release determines granulosa cell fate: cellular mechanism involved in polycystic ovaries

Journal of Ovarian Research, 2023
Polycystic ovarian syndrome (PCOS) is a complex multi-factorial syndrome associated with androgen excess and anovulatory infertility. In the current study, we investigated the role of dihydrotestosterone-induced exosomal miR-379-5p release in determining
Reza Salehi, Brandon A. Wyse, Meshach Asare-Werehene, Fereshteh Esfandiarinezhad, Atefeh Abedini, Bo Pan, Yoko Urata, Alex Gutsol, Jose L. Vinas, Sahar Jahangiri, Kai Xue, Yunping Xue, Kevin D. Burns, Barbara Vanderhyden, Julang Li, Yutaka Osuga, Dylan Burger, Seang-Lin Tan, Clifford L. Librach, Benjamin K. Tsang   +19 more
doaj   +1 more source

In Vitro Culture of Mouse Preantral Follicle in Supplemented Medium with Bone Morphogenetic Protein 15 (BMP15)

Otorhinolaryngology and Facial Plastic Surgery, 2021
Background: BMD-15 is a member of the superfamily of transforming growth factor-beta (TGF-β), which has a determinant role in fertility. This protein is essential for the development of ovarian follicles and acts mainly by binding to its receptor on the
Amene Shekarian, Zahra Nadia Sharifi, Mohammad Mahdi Nazarnejad, Amirhossein Saeinia, Shabnam Abdi   +4 more
doaj   +1 more source

Cryopreservation of swine ovarian tissue : effect of different cryoprotectants on the structural preservation of preantral follicle oocytes [PDF]

, 2009
The present study aimed to test different cryoprotectants on cryopreservation of pig ovarian tissue. Pig ovaries (n = 3) were collected at a local slaughterhouse. From each ovary, ten cortex samples were taken.
Amorima, C. A., Borges, Emily Nóbrega, Báo, Sônia Nair, Futino, Daniele Oga, Lucci, Carolina Madeira, Rocha-Junior, C. M. C., Silva, Renata Carvalho   +6 more
core   +1 more source

Histological and ultrastructural analysis of cryopreserved sheep preantral follicles [PDF]

Animal Reproduction Science, 2006
The aim of this study was to verify the histological and ultrastructural characteristics of sheep preantral follicles after exposure of ovarian tissue to cryopreservation in glycerol (GLY), ethylene glycol (EG), propanediol (PROH) or dimethyl sulfoxide (DMSO) in order to determine the optimum method to store sheep ovarian tissue for later experimental ...
Santos, Regiane R., Rodrigues, Ana Paula Ribeiro, Costa, Sonia Helena Furtado, Silva, José Roberto Viana, Matosa, Maria H.T., Lucci, Carolina Madeira, Báo, Sônia Nair, Hurk, Rob Van Den, Figueiredo, José Ricardo de   +8 more
openaire   +3 more sources

Efeito da proteína morfogenética óssea 7 (BMP-7) para a sobrevivência in vitro de folículos préantrais caprino [PDF]

, 2010
O presente trabalho foi conduzido de modo a se verificar o efeito de diferentes concentrações da BMP-7 no desenvolvimento in vitro de folículos pré-antrais caprinos.
Araújo, Valdevane Rocha, Báo, Sônia Nair, Figueiredo, José Ricardo de, Magalhães, Deborah M., Rodrigues, Ana Paula Ribeiro, Silva, Cleidson Manoel Gomes da, Silva, Gerlane Modesto da, Silva, José Roberto Viana   +7 more
core   +1 more source

FOLLICLE POPULATIONS IN MARE OVARIES: FROM PREANTRAL TO PREOVULATORY FOLLICLES

Enciclopédia Biosfera, 2015
The purpose of this study was to describe morphological and quantitative aspects of preantral and antral follicles in the equine ovary. Six ovaries were collected from necropsied mares and sliced lengthwise parallel to the ovulation fossa. The slices were fixed and processed for histological evaluation under light microscopy.
Rivas Leonel, Ellen, Bento-Silva, Viviane, Costa e Silva, Eliane Vianna, Zúccari, Carmem Estefânia Serra Neto   +3 more
openaire   +2 more sources

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

Abnormalities of early folliculogenesis and serum anti-Müllerian hormone in chinese patients with polycystic ovary syndrome

Journal of Ovarian Research, 2021
Purpose To investigate abnormalities of early folliculogenesis and Anti-Müllerian hormone (AMH) concentrations in polycystic ovary syndrome (PCOS) patients, and to analyze the association between AMH and early-stage follicle densities (FD).
Juan Du, Xiangyan Ruan, Fengyu Jin, Yanglu Li, Jiaojiao Cheng, Muqing Gu, Alfred Otto Mueck   +6 more
doaj   +1 more source

Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise [PDF]

, 2011
The mechanism of chemotherapy-induced acceleration of ovarian aging is not fully understood. We used doxorubicin, a widely used cancer chemotherapeutic, in a variety of in vivo xenograft, and in vitro models to investigate the impact of chemotherapy ...
Darzynkiewicz, Zbigniew, Heytens, Elke, Oktay, Kutluk, Soleimani, Reza   +3 more
core   +1 more source

Identification of A p300–SP1–BRD4 Transcriptional Axis as a Key Driver of AR Hyperactivation in Polycystic Ovarian Syndrome

Advanced Science, EarlyView.
This study reveals a pivotal epigenetic regulatory role for the histone acetyltransferase p300, demonstrating that its acetylation of histone 3 at lysine 18 and 27 (H3K18ac and H3K27ac), alongside the formation of the p300/BRD4/SP1 complex, drives AR activation and ovarian fibrosis in PCOS.
Zhengquan Zhu, Yihan Wang, Haiyun Chen, Xinye Yu, Tingyu Wang, Yajing Weng, Meihong Guo, Ying Huang, Gaojian Tao, Wangsen Cao, Yong Wang, Daojuan Wang   +11 more
wiley   +1 more source