Results 41 to 50 of about 5,075 (171)

In Vitro Culture of Mouse Preantral Follicle in Supplemented Medium with Bone Morphogenetic Protein 15 (BMP15)

Otorhinolaryngology and Facial Plastic Surgery, 2021
Background: BMD-15 is a member of the superfamily of transforming growth factor-beta (TGF-β), which has a determinant role in fertility. This protein is essential for the development of ovarian follicles and acts mainly by binding to its receptor on the
Amene Shekarian, Zahra Nadia Sharifi, Mohammad Mahdi Nazarnejad, Amirhossein Saeinia, Shabnam Abdi   +4 more
doaj   +1 more source

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, Volume 13, Issue 37, 3 July 2026.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Granulosa cell-derived miR-379-5p regulates macrophage polarization in polycystic ovarian syndrome

Frontiers in Immunology, 2023
Polycystic ovarian syndrome (PCOS) is associated with hyperandrogenemia and ovarian antral follicle growth arrest. We have previously demonstrated that androgen-induced exosomal release of miR-379-5p (miR379) from preantral follicle granulosa cells ...
Reza Salehi, Reza Salehi, Reza Salehi, Reza Salehi, Meshach Asare-Werehene, Meshach Asare-Werehene, Meshach Asare-Werehene, Brandon A. Wyse, Atefeh Abedini, Bo Pan, Alex Gutsol, Sahar Jahangiri, Peter Szaraz, Kevin D. Burns, Barbara Vanderhyden, Barbara Vanderhyden, Barbara Vanderhyden, Julang Li, Dylan Burger, Dylan Burger, Dylan Burger, Clifford L. Librach, Clifford L. Librach, Clifford L. Librach, Clifford L. Librach, Benjamin K. Tsang, Benjamin K. Tsang, Benjamin K. Tsang   +27 more
doaj   +1 more source

The Regulation of Apoptosis in Preantral Ovarian Follicles

Neurosignals, 2000
Less than 1% of ovarian follicles ever mature to ovulation. The remainder undergo atretic degeneration via apoptosis during development. Though the regulation of antral and preovulatory survival has been studied for many years, very little is known about the regulation of survival and development of preantral follicles.
openaire   +2 more sources

Abnormalities of early folliculogenesis and serum anti-Müllerian hormone in chinese patients with polycystic ovary syndrome

Journal of Ovarian Research, 2021
Purpose To investigate abnormalities of early folliculogenesis and Anti-Müllerian hormone (AMH) concentrations in polycystic ovary syndrome (PCOS) patients, and to analyze the association between AMH and early-stage follicle densities (FD).
Juan Du, Xiangyan Ruan, Fengyu Jin, Yanglu Li, Jiaojiao Cheng, Muqing Gu, Alfred Otto Mueck   +6 more
doaj   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, Volume 13, Issue 29, 22 May 2026.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, Volume 14, Issue 4, Page 1017-1028, May 2026.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Cytohistological Changes of the Apoptosis Ovarian Follicles in the Puberty Mouse Ovary

Scientific Papers Animal Science and Biotechnologies, 2023
Apoptosis, as a normal physiological process is active in the ovary of all species of mammals, representing the essential factor in maintaining the homeostasis of this organ.
Liliana Petculescu-Ciochina, Nicolae Păcală, Gabi Dumitrescu   +2 more
doaj  

Control of the growth and development of murine preantral follicles in a biomimetic ovary using a decellularized porcine scaffold

Materials Today Bio, 2023
This study aimed to derive mature oocytes from murine preantral follicles cultured in a biomimetic ovary with a porcine scaffold using decellularization technology.
Eun young Park, Jin hee Park, Nhu Thi Quynh Mai, Byoung-San Moon, Jung Kyu Choi   +4 more
doaj   +1 more source

A New Diagnostic Strategy for Polycystic Ovary Syndrome Combining Japanese and International Diagnostic Criteria Using Anti‐Müllerian Hormone

Journal of Obstetrics and Gynaecology Research, Volume 52, Issue 5, May 2026.
ABSTRACT Aim We had defined the anti‐Müllerian hormone (AMH) cut‐off value level 2 aligned with the Rotterdam/International Evidence‐based Guideline (IEBG) for the Assessment and Management of polycystic ovary syndrome (PCOS) 2023 criteria. In this study, we evaluated the utility of AMH cut‐off value level 2 in patients who could not be diagnosed under
Hiroki Noguchi, Takeshi Iwasa, Akira Iwase, Haruhiko Kanasaki, Fuminori Kimura, Koji Kugu, Kazuki Saito, Tsuyoshi Baba, Tetsuaki Hara, Toshiya Matsuzaki   +9 more
wiley   +1 more source