Results 41 to 50 of about 20,271 (285)

The Problem of the "Prebiotic and Never Born Proteins"

, 2012
It has been argued that the limited set of proteins used by life as we know it could not have arisen by the process of Darwinian selection from all possible proteins.
Berg, Dyson, Gerald E. Marsh, Hong, Levinthal, Miller, Oparin, Orgel   +7 more
core   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Chemical Diversity of Metal Sulfide Minerals and Its Implications for the Origin of Life

Life, 2018
Prebiotic organic synthesis catalyzed by Earth-abundant metal sulfides is a key process for understanding the evolution of biochemistry from inorganic molecules, yet the catalytic functions of sulfides have remained poorly explored in the context of the ...
Yamei Li, Norio Kitadai, Ryuhei Nakamura
doaj   +1 more source

Insights into Early Steps of Decanoic Acid Self-Assemblies under Prebiotic Temperatures Using Molecular Dynamics Simulations

Membranes, 2023
The origin of life possibly required processes in confined systems that facilitated simple chemical reactions and other more complex reactions impossible to achieve under the condition of infinite dilution.
Romina V. Sepulveda, Christopher Sbarbaro, Ma Cecilia Opazo, Yorley Duarte, Fernando González-Nilo, Daniel Aguayo   +5 more
doaj   +1 more source

Chiral Polymerization in Open Systems From Chiral-Selective Reaction Rates

, 2012
We investigate the possibility that prebiotic homochirality can be achieved exclusively through chiral-selective reaction rate parameters without any other explicit mechanism for chiral bias.
A Bakasov, A Salam, Bradley J. Nelson, C Chyba, C McKay, D Fitz, DG Fraser, DK Kondepudi, DP Glavin, F Frank, FHC Crick, J Bailey, JAD Wattis, JAD Wattis, JB Corliss, JD Dunitz, JR Cronin, LD Landau, LE Orgel, M Gleiser, M Gleiser, MA Zuilen van, Marcelo Gleiser, PC Joshi, PCW Davies, PCW Davies, PGH Sandars, R Gomes, R Hazen, R Plasson, SA Benner, Sara Imari Walker, SJ Mojzsis, W Gilbert, WA Bonner, Y Saito, Y Yamagata, Z Martins   +37 more
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Non-associative phase separation in an evaporating droplet as a model for prebiotic compartmentalization

Nature Communications, 2021
Prebiotic compartmentalization could prove essential for the evolution of life. Guo et al. show that liquid-liquid separation in an aqueous two-phase system driven by evaporation may already suffice to facilitate chemical processes required for the RNA ...
Wei Guo, Andrew B. Kinghorn, Yage Zhang, Qingchuan Li, Aditi Dey Poonam, Julian A. Tanner, Ho Cheung Shum   +6 more
doaj   +1 more source

Structural Phenomena in a Vesicle Membrane Obtained through an Evolution Experiment: A Study Based on MD Simulations

Life, 2023
The chemical evolution of biomolecules was clearly affected by the overall extreme environmental conditions found on Early Earth. Periodic temperature changes inside the Earth’s crust may have played a role in the emergence and survival of functional ...
María J. Dávila, Christian Mayer
doaj   +1 more source

Identification of the prebiotic translation apparatus within the contemporary ribosome [PDF]

, 2009
A structural element that could have existed independently in the prebiotic era was identified at the active site of the contemporary ribosome. It is suggested to have functioned as a proto-ribosome catalyzing peptide bond formation and non-coded ...
Ada Yonath, Anat Bashan, Chen Davidovich, Ilana Agmon   +3 more
core   +1 more source

Template coexistence in prebiotic vesicle models

, 2005
The coexistence of distinct templates is a common feature of the diverse proposals advanced to resolve the information crisis of prebiotic evolution.
Alves, Aoki, Bresch, Chen, D. G.M. Silvestre, Donato, Donato, Doudna, Eigen, Eigen, Eshel, Fox, Grey, Hamilton, Hanczyc, J. F. Fontanari, Michod, Niesert, Rainey, Sachs, Sachs, Segre, Silva, Smith, Smith, Swetina, Szathmáry, Szathmáry, Velicer, Wade, Wright, Zintzaras   +31 more
core   +2 more sources