Results 61 to 70 of about 20,271 (285)

An Extended Model for the Evolution of Prebiotic Homochirality: A Bottom-Up Approach to the Origin of Life

, 2008
A generalized autocatalytic model for chiral polymerization is investigated in detail. Apart from enantiomeric cross-inhibition, the model allows for the autogenic (non-catalytic) formation of left and right-handed monomers from a substrate with reaction
A Brandenburg, A Brandenburg, D Fitz, DG Blackmond, DK Kondepudi, FC Frank, GF Joyce, H Haken, JA Wattis, JD Dunitz, JD Gunton, JS Langer, K Soai, M Gleiser, M Gleiser, M Nilsson, Marcelo Gleiser, MH Engel, N Goldenfeld, PGH Sandars, PGH Sandars, S Pizzarello, Sara Imari Walker, Y Yamagata   +23 more
core   +1 more source

The Central Symbiosis of Molecular Biology: Molecules in Mutualism. [PDF]

, 2017
As illustrated by the mitochondrion and the eukaryotic cell, little in biology makes sense except in light of mutualism. Mutualisms are persistent, intimate, and reciprocal exchanges; an organism proficient in obtaining certain benefits confers those on ...
Lanier, Kathryn A, Petrov, Anton S, Williams, Loren Dean   +2 more
core   +2 more sources

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

A Realistic Model under which the Genetic Code is Optimal [PDF]

, 2013
The genetic code has a high level of error robustness. Using values of hydrophobicity scales as a proxy for amino acid character, and the Mean Square measure as a function quantifying error robustness, a value can be obtained for a genetic code which ...
Buhrman, Harry, Klau, Gunnar W., Schaffner, Christian, Speijer, Dave, Stougie, Leen, van der Gulik, Peter T. S.   +5 more
core   +5 more sources

Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy

Advanced Science, EarlyView.
This study constructed the W1/O/W2 emulsion–based targeted therapy delivery system for ulcerative colitis (UC) utilizing LCC as surfactant for the first time. This multifunctional emulsion offered certain therapeutic advantages for UC, including targeted colonic delivery of active compounds, synergistic modulation of gut microbiota through combined ...
Qian Wu, Xingyu Zhang, Jingjia Zhang, Gaohui Huang, Chen Zhou, Chunlin Li, Xiaojun Huang, Jianbo Xiao, Nianjie Feng, Yuanbin She   +9 more
wiley   +1 more source

Exposed Areas Above Sea Level on Earth >3.5 Gyr Ago: Implications for Prebiotic and Primitive Biotic Chemistry

Life, 2018
How life began on Earth is still largely shrouded in mystery. One of the central ideas for various origins of life scenarios is Darwin’s “warm little pond„. In these small bodies of water, simple prebiotic compounds such as amino acids,
Jeffrey L. Bada, Jun Korenaga
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Toward stable replication of genomic information in pools of RNA molecules

eLife
The transition from prebiotic chemistry to living systems requires the emergence of a scheme for enzyme-free genetic replication. Here, we analyze a recently proposed prebiotic replication scenario, the so-called Virtual Circular Genome (VCG) [Zhou et al.
Ludwig Burger, Ulrich Gerland
doaj   +1 more source

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

From Cosmos to Intelligent Life: The Four Ages of Astrobiology

, 2012
The history of life on Earth and in other potential life-bearing planetary platforms is deeply linked to the history of the universe. Since life as we know it relies on chemical elements forged in dying heavy stars, the universe needs to be old enough ...
Abel, Arrhenius, Bonner, Fenchel, Fitz, Gleiser, Kaltenegger, Lunine, Marcelo Gleiser, Oparin, Prigogine, Salama, Smoot, Susskind, Susskind, Ward, Webb, Weinberg   +17 more
core   +1 more source