Results 61 to 70 of about 8,350,584 (283)

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang, Xueying Wang, Shanhong Lu, Yan Gao, Gangcai Zhu, Guo Li, Zongnan Yu, Junwei Hou, Helei Yan, Wenhui Yuan, Xin Zhang, Mien‐Chie Hung, Zhifeng Liu, Yong Liu   +13 more
wiley   +1 more source

IN VIVO CONFOCAL MICROENDOSCOPY: FROM THE PROXIMAL BRONCHUS DOWN TO THE PULMONARY ACINUS

Вестник трансплантологии и искусственных органов, 2013
In vivo endoscopic microscopy aims to provide the clinician with a tool to assess architecture and morphology of a living tissue in real time, with an optical resolution similar to standard histopathology.
L. Thiberville, M. Salaün, G. Bourg-Heckly   +2 more
doaj   +1 more source

Real‐Time Evolutionary Landscape of the Bronchial Epithelium and Corresponding Dynamic Immune Cell Alterations in Lung Squamous Cell Carcinogenesis

Advanced Science, EarlyView.
Lung squamous cell carcinoma (LUSC) is often preceded by sequential premalignant lesions with an increasing probability of malignant progression. Using single‐cell RNA sequencing, the dynamic cellular evolution from normal lung to LUSC tissues is delineated; clonal structure of premalignant and malignant epithelium is reveled; the conversion of immune ...
Baohong Luo, Yuting Luo, Sicheng Chen, Tiantian Yang, Bixia Liu, Xiting Liao, Xiaoke Zheng, Tian Tian, Jinxu Liu, Qinru Zhan, Xiaohua Situ, Zhongpeng Xie, Yanxia Wang, Zhe‐Sheng Chen, Honglei Chen, Zheng Yang, Zunfu Ke   +16 more
wiley   +1 more source

A comparative study to assess the increased expression of programmed cell death-1 (PD1) and programmed cell death- ligand-1 (PDL1) in oral potentially malignant disorders and oral squamous cell carcinoma

Journal of Indian Academy of Oral Medicine and Radiology, 2023
Background: Programmed cell death-1 (PD-1) is expressed on the surface of activated T cells, while its ligand, PD-L1, is expressed on the surface of dendritic cells or macrophages. Objective: This study assessed the increased expression of PD-1 and PD-L1
Sonalika Srivastava, Abhishek Sinha, Sunita Srivastava, Anuj Mishra   +3 more
doaj   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

El cáncer cervicouterino y las lesiones precursoras: revisión bibliográfica Cervical-uterine cancer and precursor lesions: a literature review

Revista de Ciencias Médicas de Pinar del Río, 2011
Con el objetivo de actualizar el estado del arte sobre el cáncer cervicouterino y las lesiones precursoras se realizó una revisión bibliográfica de los artículos publicados en los últimos 5 años, y de otros originales teniendo en cuenta su nivel de ...
José Guillermo Sanabria Negrín, Zoila C Fernández Montequín, Inalvis de la Caridad Cruz Hernández, Leonardo Oriolo Pérez, Margarita Llanuch Lara   +4 more
doaj  

The diagnostic and prognostic utility of insulin growth factor of squamous cell carcinoma in oral cavity

Tzu Chi Medical Journal, 2021
Objective: The present study was conducted to find the utility of insulin growth factors (IGFs) as diagnostic and prognostic biochemical parameters in patients suffering from squamous cell carcinoma of oral cavity.
Sumit Kumar Tiwari, Shakuntala Saini, Pawan Singhal, Ashwin Mathur, Maheep Sinha   +4 more
doaj   +1 more source

Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression

Advanced Science, EarlyView.
Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu, Lin Jing, Yixin Li, Jinxing Zhou, Xiaohui Cui, Sen Li, Shijie Yang, Fangming Kan, Junfeng Du, Wentao Zhong, Sheng Yu, Ning Wang, Xing Jia, Junhui Li, Pan Nie, Zhenzhong Chen, Ying Han, Lingxi Jiang, Xiyun Yan, Hongxia Duan, Baiyong Shen   +20 more
wiley   +1 more source

DECENA - cervical cancer primary screening program in Vojvodina [PDF]

Archive of Oncology, 2007
Hc2 DNA test for detection of 13 oncogenic human papillomavirus genotypes (16/18/31/33/35/39/45/51/52/56/58/59/68) is a real partner to cytology, concerning improvement and better detection of premalignant and malignant cervical diseases.
Rajović Jelka, Andrijević Ljiljana, Fajka Robert, Fenyvesi Attila, Malobabić Dragan, Ćuk Dragomir, Korovljev Jelena, Kmezić Vesna, Štajer Laslo, Barišić Aleksandar, Mašić Adela   +10 more
doaj   +1 more source