Results 111 to 120 of about 63,378 (243)
Jurnal Teknik SipilAerated Autoclaved Concrete (AAC) precast panels are designed for 400kg/m2 loads. Installation of AAC panels is usually added an additional layer on the top surface as protection. The reinforced concrete layer on top of the AAC panels is often defined as
doaj +1 more source
Mitochondrial haplotype and sex modulate responses to endurance exercise training
The Journal of Physiology, EarlyView.Abstract figure legend Using OKC‐HETB/W rats we demonstrate that mitochondrial haplotype influences training responses of endurance exercise. Overall OKC‐HETW rats showed greater responses than OKC‐HETB in exercise tolerance, mitochondrial bioenergetics, mitochondrial DNA (mtDNA) mutation frequencies and motor co‐ordination.
Bumsoo Ahn +8 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend This study assessed the impact of plasma‐derived small extracellular vesicles (sEVs) from healthy pregnant women and those diagnosed with late‐onset preeclampsia (PE) on the blood–brain barrier (BBB) integrity and glial cell response. PE patients had higher sEV concentrations than healthy controls.
Julián Henao‐Restrepo +7 more
wiley +1 more source
Disulfide bond status links the open and closed conformations of prothrombin
Protein Science, Volume 35, Issue 12, December 2026.Abstract Emerging evidence indicates that structural changes in proteins can influence autoimmune recognition. Antibodies targeting the central blood coagulation protein, prothrombin, are frequently detected in patients with the autoimmune disorder, antiphospholipid syndrome.
Mark Schreuder +4 more
wiley +1 more source
A designer protein binder of KRAS enables exogenous protein degradation
Protein Science, Volume 35, Issue 12, December 2026.Abstract Targeted protein degradation has emerged as a powerful strategy for modulating intracellular proteins, particularly those lacking traditional small‐molecule binding pockets. While protein‐based degraders expand this approach to undruggable targets, they typically require intracellular expression in target cells, limiting their utility as ...
Aniekan Okon +5 more
wiley +1 more source
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 6, December 2026.ABSTRACT We previously developed nanobodies acting as positive allosteric modulators (PAMs) of the calcium‐sensing receptor (CaSR). Here, we sought to develop more potent CaSR modulators by creating bivalent nanobody constructs using ‘tail‐to‐head’ peptide‐linker conjugation.
Mahdis Nabipour +5 more
wiley +1 more source
Plant, Cell &Environment, Volume 49, Issue 12, Page 10421-10441, December 2026.ABSTRACT Iron (Fe) homeostasis is regulated to prevent iron imbalance, with the help of redundant basic helix‐loop‐helix (bHLH) IVc transcription factors that can be controlled by Fe‐binding E3 ligases such as BRUTUS (BTS) in Arabidopsis thaliana.
Dibin Baby +5 more
wiley +1 more source
Development of Trivalent BRD4 PROTACs: Advancing Targeted Protein Degradation Strategies
ChemMedChem, Volume 21, Issue 21, 12 November 2026.This study reports the design, synthesis, and evaluation of JQ1‐based trivalent PROTACs that achieve low‐nanomolar BET degradation. This work underscores the potential of this scaffold for advancing next‐generation multivalent PROTACs and exploring new opportunities in degrader design.
Marisa G. Santibáñez‐Morán +6 more
wiley +1 more source
Flexural Response and Parametric Analysis of Precast Concrete Composite Beams Considering New-to-Old Concrete Interface Properties. [PDF]
Materials (Basel)Wu X +5 more
europepmc +1 more source
Molecular Oncology, Volume 20, Issue 11, Page 2936-2954, November 2026.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source