Results 131 to 140 of about 63,378 (243)

Ursodeoxycholic Acid Confers Neuroprotection in Rats With Acute Cervical SCI and Attenuates NLRP3/Caspase‐1/GSDMD Pyroptotic Signaling

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Ursodeoxycholic Acid could inhibit activation of the NLRP3/Caspase‐1/GSDMD pyroptosis pathway and reduce the release of downstream inflammatory cytokines IL‐18 and IL‐1β in rats with acute C5 cervical SCI. This modulation is associated with attenuated secondary injury and improved functional outcomes.
Honghu Song   +10 more
wiley   +1 more source

Dichloroacetate Improves Animal Survival, Growth, Neuromuscular Activity, Mitochondrial Stress and Physiology, and Elevated Lactate in C. elegans pdha‐1 and dld‐1 RNAi Models of Pyruvate Dehydrogenase Complex Deficiency (PDCD)

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Pyruvate dehydrogenase complex (PDHc) deficiency (PDCD) is a primary mitochondrial disorder characterized by neurodevelopmental disability, altered intermediary metabolism, and early mortality. Dichloroacetate (DCA), a pyruvate analog, activates PDHc and remains under clinical investigation for treatment of PDCD.
Cristina Remes   +10 more
wiley   +1 more source

Polyomavirus Drives Cerebellar Lesions in AIDS Monkeys With Ataxia

open access: yesMedComm, Volume 7, Issue 11, November 2026.
Chronic SIV‐infected macaques with ataxia develop severe cerebellar lesions driven by simian polyomavirus 40 (SV40) infection. SV40 preferentially infects cerebellar granule cells, inducing pyroptosis and an aberrant proliferative state. Pyroptotic neuronal injury promotes microglial recruitment and activation, amplifying local neuroinflammation and ...
Tian‐Zhang Song   +9 more
wiley   +1 more source

Long‐Read Reference Transcriptomes for Five Species of Rosaceae Tribe Spiraeeae: A Resource for Investigating Sequence Divergence, Species‐Associated Expression Variation, and Leaf‐Developmental Candidate Genes

open access: yesPlant Direct, Volume 10, Issue 11, November 2026.
ABSTRACT Species in the Rosaceae tribe Spiraeeae occupy diverse habitats and vary strikingly in growth form and leaf morphology. Still, no reference transcriptomes have been published for the tribe, and its transcriptome‐level variation is uncharacterized.
Armin M. Mafakheri, Daniel Potter
wiley   +1 more source

Multi‐Omics Reveals STAT1 as a Central Regulator of Oxidative Stress‐Induced Senescence in the Aging Retina

open access: yesAging Cell, Volume 25, Issue 11, November 2026.
Integrated multi‐omics identifies STAT1 as a central regulator of retinal aging, linking oxidative stress, inflammation, and senescence at neuro‐glial interfaces. ABSTRACT Aging is the dominant risk factor for retinal neurodegeneration, yet the upstream regulators that coordinate senescence‐associated programs across retinal cell types remain ...
Yiran Fan   +9 more
wiley   +1 more source

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