Results 141 to 150 of about 63,378 (243)

Decoding neuronal vulnerability: Multidimensional analysis of D1R‐ and D2R‐ medium‐sized spiny neurons in Huntington's disease

open access: yesBrain Pathology, Volume 36, Issue 6, November 2026.
D1R and D2R MSNs show distinct responses to Huntington's pathology. G&T‐sequencing of pre‐symptomatic MSNs reveals global LINE‐1 downregulation. While D1R‐MSNs display early transcriptomic changes (OXPHOS/translation upregulation) and reduced mutant huntingtin aggregation, D2R‐MSNs exhibit higher nuclear mHTT accumulation and greater CAG somatic ...
Guendalina Bergonzoni   +22 more
wiley   +1 more source

Adiponectin promotes AMPA receptor trafficking and enhances excitatory synaptic transmission at hippocampal synapses via AMP‐activated protein kinase signalling

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 21, Page 6501-6518, November 2026.
Background and Purpose Peripherally derived adiponectin crosses the blood–brain barrier and targets severa0l brain regions. Adiponectin receptors are highly expressed in the hippocampus, and play a pro‐cognitive role as adiponectin markedly influences the functioning of hippocampal synapses.
Alexandra Soca   +4 more
wiley   +1 more source

High‐variance phenome database reveals important roles of WD40 proteins in the plant pathogenic fungus Fusarium graminearum

open access: yesNew Phytologist, Volume 252, Issue 3, Page 1215-1231, November 2026.
Functional analysis of predicted interaction‐associated WD40 blades in Fgwd101 and Fgwd048 of Fusarium graminearum. Summary WD40 is a highly conserved protein domain in eukaryotes that functions as a versatile platform for protein–protein interactions and participates in diverse biological processes.
Soyoung Choi   +15 more
wiley   +1 more source

Respirasome Persistence Without Efficient Electron Channeling in Cardiac Mitochondria From an Animal Model of Hypertension

open access: yesAnnals of the New York Academy of Sciences, Volume 1565, Issue 1, November 2026.
ABSTRACT Cardiac mitochondrial dysfunction contributes to hypertensive remodeling, but whether respiratory supercomplex organization preserves electron transfer efficiency during disease progression remains unresolved. Here, we examined the structural and functional organization of the respiratory complexes in cardiac mitochondria from stroke‐resistant
Patrycja Anna Glogowski   +8 more
wiley   +1 more source

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