Results 81 to 90 of about 763,867 (328)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

US legal system in the context of English legal heritage and theory of the natural rights of John Locke [PDF]

open access: yesStrani pravni život, 2018
The paper discusses several characteristics of the US legal system that rest upon English legal heritage, brought from England to North America by the first colonists.
Bekčić-Pješčić Gordana
doaj  

A New Basis Function Approach to 't Hooft-Bergknoff-Eller Equations [PDF]

open access: yes, 1999
We analytically and numerically investigate the 't Hooft-Bergknoff-Eller equations, the lowest order mesonic Light-Front Tamm-Dancoff equations for U(N_C) and SU(N_C) gauge theories.
A. Duncan   +22 more
core   +4 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

LA FUERZA VINCULANTE DE LAS SENTENCIAS CONSTITUCIONALES Y EL RECONOCIMIENTO DE DERECHOS FUNDAMENTALES.: A PROPÓSITO DE LA LEY SOBRE REGULACIÓN DE LA FERTILIDAD THE BINDING FORCE OF THE CONSTITUTIONAL RULINGS AND THE RECOGNITION OF FUNDAMENTAL RIGHTS.: ON PURPOSE OF THE BILL ABOUT FERTILITY REGULATION

open access: yesRevista Chilena de Derecho, 2010
Se discute el impacto de las decisiones del Tribunal Constitucional, en su rol de supremo intérprete de la Constitución, sobre los demás poderes del Estado, particularmente sobre el Gobierno y el Congreso, en especial cuando sus sentencias versan sobre ...
GONZALO CARREÑO PAVEZ   +1 more
doaj  

Impeachment as Congressional Constitutional Interpretation [PDF]

open access: yes, 2000
Katyal argues that one can adhere to originalism in the context of judicial interpretation and, nevertheless, believe in a broader style of interpretation for the legislature. He illustrates the point with three examples--the roles of history, precedent,
Katyal, Neal Kumar
core   +1 more source

The Ebola clinical trials: a precedent for research ethics in disasters

open access: yesJournal of Medical Ethics, 2016
The West African Ebola epidemic has set in motion a collective endeavour to conduct accelerated clinical trials, testing unproven but potentially lifesaving interventions in the course of a major public health crisis.
P. Calain
semanticscholar   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

RACIAL SEGREGATION AS A MANIFESTATION OF IDEOLOGICAL EXTREMISM: THE EXAMPLE OF THE CASE “PLESSY V. FERGUSON” [PDF]

open access: yesLegal Bulletin
Relevance. The topic of racial segregation and the struggle for civil rights in the United States continues to be relevant. Precedential decisions of the US Supreme Court on issues of racial segregation still influence the development of American society
KHAPCHAEV S.T., KOKOREV V.G.
doaj   +1 more source

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