Results 101 to 110 of about 163,476 (344)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

The Concept of Stare Decisis in the German Legal System – a Systematically Inconsistent Concept with High Factual Importance

open access: yesStudia Iuridica Lublinensia, 2018
It is worth mentioning that the German legal system is based on the codified law. This system lacks in stare decisis and precedents in general, which – in principle – does not raise doubts.
Peter Stainer, Dominik König
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang   +10 more
wiley   +1 more source

Agency-Specific Precedents

open access: yes, 2011
As a field of legal study and practice, administrative law rests on the premise that legal principles concerning agency structure, administrative process, and judicial review cut across multiple agencies.
Levy, Robert E.   +2 more
core  

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang   +6 more
wiley   +1 more source

The importance of precedents in Shylock’s judgment in Shakespeare’s "The Merchant of Venice"

open access: yesAnamorphosis, 2017
This paper sets out to show the importance of judicial precedents by examining Shakespeare's The Merchant of Venice, since the theory of binding precedents, originally known as stare decisis, has its origin in British law.
Gustavo Santana Nogueira
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende   +26 more
wiley   +1 more source

El Rol Uniformador de la Jurisprudencia de la Sala Penal de la Corte Suprema: Estudio empírico

open access: yesIus et Praxis, 2007
La Corte Suprema chilena cuenta desde 1995 con salas especializadas para conocer determinadas materias. Uno de los principales objetivos de la reforma que creó esas salas consistió en asegurar una aplicación más cierta y uniforme de la ley.
Jaime Couso, Jorge Mera
doaj  

Del precedente judicial a los precedentes obligatorios: ¿Ventaja o amenaza para los Tribunales Inferiores?

open access: yesRevista Interdisciplinar de Direito, 2018
The theories of legal argumentation, globalization in the legal field and the consolidation of constitutional jurisdictions have promoted the progressive centrality of jurisprudence in our days, thanks to the leading role recognized in the judicial ...
Nuria Belloso Martín
doaj   +1 more source

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