Results 91 to 100 of about 2,435,105 (382)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Estimating the uncertainty of areal precipitation using data assimilation [PDF]

, 2019
We present a method to estimate spatially and temporally variable uncertainty of areal precipitation data. The aim of the method is to merge measurements from different sources, remote sensing and in situ, into a combined precipitation product and to ...
Ament, F., Clemens, M., Geppert, G., Merker, C.   +3 more
core   +1 more source

A Composite Approach for Evaluating Operational Cloud Seeding Effect in Stratus Clouds

Hydrology
Robust water management is in intense demand in many water scarcity areas, such as arid and semi-arid regions in the world. As part of the regional water management strategy, rain enhancement is vital to replenish groundwater reservoirs, and the key ...
Fei Wang, Baojun Chen, Zhiguo Yue, Jin Wang, Dejun Li, Dawei Lin, Yahui Tang, Tian Luan   +7 more
doaj   +1 more source

Influence of the Background Nitrogen Oxides on the Tropospheric Ozone Depletion Events in the Arctic during Springtime

Atmosphere, 2020
Ozone depletion events (ODEs) in the springtime of the Arctic have been frequently observed since the early 1980s, and the correlation between the ozone mixing ratio during the ODEs and the nitrogen oxides (NOx) concentration is still unclear.
Jiashu Zhou, Le Cao, Simeng Li
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

An examination of the precipitation delivery mechanisms for Dolleman Island, eastern Antarctic Peninsula [PDF]

, 2004
Copyright @ 2004 Wiley-BlackwellThe variability of size and source of significant precipitation events were studied at an Antarctic ice core drilling site: Dolleman Island (DI), located on the eastern coast of the Antarctic Peninsula.
ANDREW RUSSELL, Bromwich D. H., Bromwich D. H., Carleton A. M., Ciais P., Cullather R. I., Delaygue G., GARETH J. MARSHALL, Genthon C., GLENN R. MCGREGOR, Mulvaney R., Noone D., Peel D. A., Peel D. A., Peel D. A., Rott H., Schlosser E., Skvarca P., Stocker T. F., Turner J., Turner J.   +20 more
core   +1 more source

Analysis of a Haze Event over Nanjing, China Based on Multi-Source Data

Atmosphere, 2019
We analyzed a June 2018 Nanjing, China haze event using ground-based and spaceborne sensors, combined with sounding and HYSPLIT backward trajectory data, with the ground-based and spaceborne sensor data exhibiting good consistency.
Yiyang Zhang, Jing Wang, Lingbing Bu
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Pattern scaling using ClimGen: monthly-resolution future climate scenarios including changes in the variability of precipitation [PDF]

, 2015
Development, testing and example applications of the pattern-scaling approach for generating future climate change projections are reported here, with a focus on a particular software application called “ClimGen”.
C Huntingford, C Tebaldi, Craig J. Wallace, DB Stephenson, DP Vuuren van, G Meehl, I Harris, I Watterson, Ian C. Harris, J Heinke, JFB Mitchell, JM Murphy, JM Murphy, KE Taylor, M New, MF Cabré, N Arnell, NA Rayner, NW Arnell, R Warren, R Warren, SFB Tett, TD Mitchell, Thomas M. Melvin, Timothy J. Osborn, TJ Osborn, Y Ishizaki, Y Ishizaki   +27 more
core   +1 more source

Spatial and Temporal Distribution Characteristics and Source Apportionment of VOCs in Lianyungang City in 2018

Atmosphere, 2021
From April to September 2018, five sampling sites were selected in Lianyungang City for volatile organic compounds (VOCs) analysis, including two sampling sites in the urban area (Lianyungang City Environmental Monitoring Supersite and Mine Design ...
Cheng Chen, Lingrui Wang, Yunjiang Zhang, Shanshan Zheng, Lili Tang   +4 more
doaj   +1 more source