Results 91 to 100 of about 1,623,514 (364)

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

The transient response of global-mean precipitation to increasing carbon dioxide levels [PDF]

, 2010
The transient response of global-mean precipitation to an increase in atmospheric carbon dioxide levels of 1% yr(-1) is investigated in 13 fully coupled atmosphere-ocean general circulation models (AOGCMs) and compared to a period of stabilization ...
Bala G, Meehl G A, Mitchell J F B, Piers M Forster, Timothy Andrews, Wild M   +5 more
core   +1 more source

Simulations of Summertime Ozone and PM_2.5 Pollution in Fenwei Plain (FWP) Using the WRF-Chem Model

Atmosphere, 2023
In recent years, ozone and PM2.5 pollution has often occured in the Fenwei Plain due to heavy emission and favorable geographical conditions. In this study, we used the weather research and forecasting/chemistry (WRF-Chem) model to reproduce the complex ...
Yuxi Wang, Le Cao, Tong Zhang, Haijiang Kong   +3 more
doaj   +1 more source

Stable water isotopes in HadCM3: isotopic signature of El Nino-Southern Oscillation and the tropical amount effect [PDF]

, 2009
Stable water isotopes have been added to the full hydrological cycle of the Hadley Centre Climate model (HadCM3) coupled atmosphere-ocean GCM. Simulations of delta O-18 in precipitation and at the ocean surface compare well with observations for the ...
Sime, Louise C., Tindall, J. C., Valdes, P.J.   +2 more
core   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Quantification of Dislocation-Precipitate Interactions [PDF]

arXiv, 2017
The present research is the first attempt to systematically quantify the dislocation-precipitate interaction in terms of applied shear stress, precipitate resistance, and the required time to reach the critical state of dislocation-precipitate interaction when a dislocation line is about to pass through precipitates.
arxiv  

Climate Dynamics: A Network-Based Approach for the Analysis of Global Precipitation [PDF]

, 2013
Precipitation is one of the most important meteorological variables for defining the climate dynamics, but the spatial patterns of precipitation have not been fully investigated yet. The complex network theory, which provides a robust tool to investigate
A Becker, A Gozolchiani, A Kolzsch, AA Tsonis, AA Tsonis, AA Tsonis, AJ Simmons, Alex J. Cannon, AS Cofiño, B Rajagopalan, C Chou, D Hemming, DJ Watts, DL Montroy, DR Archer, F Raicich, Francesco Laio, GJ McCabe, GJ van Oldenborgh, J Heitzig, J Kennedy, J Kennedy, J Kennedy, J Shaman, JE Hansen, JF Diaz, JF Donges, JF Donges, JF Donges, JM Ryoo, JP Boulanger, JW Hurrell, K Steinhaeuser, K Yamasaki, KF Davis, LC Freeman, LD Costa, LD Costa, LL Chen, Luca Ridolfi, M Fritsche, M Palus, MEJ Newman, N Malik, R Albert, R Cano, RH Kripalani, S Abe, S Boccaletti, S Brönnimann, S Fatichi, S Michaelides, S Saeed, SE Nicholson, Stefania Scarsoglio, T Zhou, U Gessner, U Schneider, V Petoukhova, W Chen   +59 more
core   +4 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Aircraft Observations of Ice Particle Properties in Stratiform Precipitating Clouds

Advances in Meteorology, 2014
This study presented airborne measurements of ice particle properties in three stratiform precipitating clouds over northern China. By using horizontal observations at selected altitudes, the distributions of ice water content (IWC), particle habits, and
Tuanjie Hou, Hengchi Lei, Zhaoxia Hu, Jun Zhou   +3 more
doaj   +1 more source